25428-06-2

Basic information

• Product Name: Ethanone, 1-(2-amino-5-methylphenyl)- (9CI)
• Synonyms: Ethanone, 1-(2-amino-5-methylphenyl)- (9CI);1-(2-Amino-5-methyl-phenyl)-ethanone;Ethanone, 1-(2-amino-5-methylphenyl)-
• CAS NO: 25428-06-2
• Molecular Formula: C₉H₁₁NO
• Molecular Weight: 149.18974
• Product Categories: ACETYLGROUP
• Mol File: 25428-06-2.mol
• Article Data: 20

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Ethanone, 1-(2-amino-5-methylphenyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-(2-amino-5-methylphenyl)- (9CI)(25428-06-2)
• EPA Substance Registry System: Ethanone, 1-(2-amino-5-methylphenyl)- (9CI)(25428-06-2)

Safety Data

• Hazardous Substances Data: 25428-06-2(Hazardous Substances Data)

Upstream product

• 103-89-9 4-Methylacetanilide 
• 2759-54-8 N-(4-chlorophenyl)propionamide 
• 69976-70-1 1-(5-methyl-2-nitrophenyl)-ethanone 
• 21296-92-4 2,3,5-trimethyl-1H-indole 
• 38818-49-4 5-methyl-2-nitrobenzoyl chloride 
• 106-49-0 p-toluidine 
• 75-05-8 acetonitrile 
• 1438400-35-1 N-(2-acetyl-4-methylphenyl)-4-methylbenzenesulfonamide 
• 2941-78-8 2-Amino-5-methylbenzoic acid 
• 917-54-4 methyllithium 
• 180624-14-0 4-methyl-2-[2-(trimethylsilyl)ethynyl]aniline 
• 215589-37-0 2-ethynyl-4-methylaniline 
• 29289-13-2 2-iodo-4-methylaniline 
• 5925-93-9 2-amino-5-methylbenzonitrile 

Downstream Products

• 73129-52-9 2'-chloro-5-methylacetophenone 
• 38968-41-1 1-(2-azido-5-methylphenyl)ethan-1-one 
• 326852-80-6 6-(2-acetyl-4-methyl-phenylamino)quinoline-5,8-dione 
• 887002-04-2 N-(2-acetyl-4-methyl-phenyl)-2-chloro-acetamide 

Relevant articles and documents

Catalytic Asymmetric Addition of Diorganozinc Reagents to Pyrazole-4,5-Diones and Indoline-2,3-Diones

The catalytic enantioselective diorganozinc additions to cyclic diketones including pyrazolin-4,5-diones and isatins have been developed. In the presence of morpholine-containing chiral amino alcohol ligand, the corresponding chiral cyclic tertiary alcohols were produced in good to excellent yields (up to 97 %) and enantioselectivities (up to 95 % ee). The notable feature of this protocol includes its mild reaction conditions, Lewis acid additives free and broad functional group tolerance.

Copper-Catalyzed Chemoselective Cyclization Reaction of 2-Isocyanoacetophenone: Synthesis of 4-Hydroxyquinoline Compounds

A copper-catalyzed intramolecular cyclization reaction of 2-isocyanoacetophenone derivatives to afford 4-hydroxyquinolines chemoselectively is described. The transformation proceeds through enol tautomerism and a subsequent C-C bond formation. Compared to previous methods, this study provides a new protocol for the construction of 4-hydroxyquinoline compounds from functionalized isocyanides under mild conditions.

Catalyst-free geminal aminofluorination of ortho-sulfonamide-tethered alkylidenecyclopropanes via a Wagner-Meerwein rearrangement

A catalyst-free intramolecular geminal aminofluorination of ortho-sulfonamide-tethered alkylidenecyclopropanes has been developed. The reaction proceeded through two SET processes with Selectfluor to give a fluorinated cyclopropylcarbinyl cation and a further Wagner-Meerwein rearrangement to generate a cyclobutyl carbocation, which undergoes intramolecular nucleophilic capture by amide to forge fluorinated cyclobuta[b]indoline derivatives. A polycyclic multi-fluorinated byproduct was also formed through a Ritter-type reaction in some cases.