254749-11-6

Basic information

• Product Name: 2-CHLORO-4-CYANOBENZENESULFONYL CHLORIDE
• Synonyms: 2-CHLORO-4-CYANOBENZENE-1-SULFONYL CHLORIDE;2-CHLORO-4-CYANOBENZENESULFONYL CHLORIDE;2-CHLORO-4-CYANOBENZENESULPHONYL CHLORIDE;BUTTPARK 96\50-27;Benzenesulfonyl chloride, 2-chloro-4-cyano- (9CI);2-Chloro-4-cyanobenzenesulphonyl chloride, 95%+;3-Chloro-4-(chlorosulphonyl)benzonitrile;2-Chloro-4-cyanobenzenesulfonyl chloride 96%
• CAS NO: 254749-11-6
• Molecular Formula: C7H3Cl2NO2S
• Molecular Weight: 236.08
• Product Categories: SULFONYLHALIDE;Benzenesulfonyl chloride;Organic Building Blocks;Sulfonyl Halides;Sulfur Compounds
• Mol File: 254749-11-6.mol
• Article Data: 2

Chemical Properties

• Melting Point: 102-106 °C
• Boiling Point: 348.9 °C at 760 mmHg
• Flash Point: 164.8 °C
• Appearance: /
• Density: 1.65 g/cm³
• Vapor Pressure: 4.89E-05mmHg at 25°C
• Refractive Index: 1.616
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-CHLORO-4-CYANOBENZENESULFONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-4-CYANOBENZENESULFONYL CHLORIDE(254749-11-6)
• EPA Substance Registry System: 2-CHLORO-4-CYANOBENZENESULFONYL CHLORIDE(254749-11-6)

Safety Data

• Hazard Codes: C,Xi
• Statements: 34-43
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 1759 8/PG 3
• WGK Germany: 3
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 254749-11-6(Hazardous Substances Data)

Usage

Description

2-Chloro-4-cyanobenzenesulfonyl Chloride is an organic chemical compound characterized by the presence of a chloro, cyano, and benzenesulfonyl chloride functional groups. It is a versatile intermediate in the synthesis of various pharmaceuticals and organic compounds due to its unique reactivity and functional group compatibility.

Uses

Used in Pharmaceutical Industry:
2-Chloro-4-cyanobenzenesulfonyl Chloride is used as a key intermediate in the synthesis of Hydroxysulfonyloxaazaspirodecanylaminopropoxybenzenesulfonamide derivatives. These derivatives serve as beta-3 adrenergic receptor modulators, which have potential applications in the treatment of various medical conditions, such as obesity and related metabolic disorders, by modulating the activity of the beta-3 adrenergic receptor.

InChI:InChI=1/C7H3Cl2NO2S/c8-6-3-5(4-10)1-2-7(6)13(9,11)12/h1-3H

Upstream product

• 21803-75-8 4-amino-3-chlorobenzonitrile 
• 6574-99-8 3,4-dichloro-benzonitrile 

Downstream Products

• 1062558-95-5 3-chloro-4-(morpholine-4-sulfonyl)benzaldehyde 

Relevant articles and documents

NOVEL TETRAZOLE COMPOUNDS AND THEIR USE IN THE TREATMENT OF TUBERCULOSIS

The invention relates to a compound of Formula (I) or a pharmaceutically acceptable salt thereof and their use in therapy, for example in the treatment of mycobacterial infections or in the treatment of diseases caused by mycobacterium, such as tuberculosis.