254888-05-6

Basic information

• Product Name: Carbamic acid, [(1S)-1-formyl-2-methylbutyl]-, 1,1-dimethylethyl ester (9CI)
• Synonyms: Carbamic acid, [(1S)-1-formyl-2-methylbutyl]-, 1,1-dimethylethyl ester (9CI)
• CAS NO: 254888-05-6
• Molecular Formula: C₁₁H₂₁NO₃
• Molecular Weight: 215.28934
• Product Categories: N-BOC
• Mol File: 254888-05-6.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 295.5±23.0 °C(Predicted)
• Appearance: /
• Density: 0.976±0.06 g/cm3(Predicted)
• PKA: 11.43±0.46(Predicted)
• CAS DataBase Reference: Carbamic acid, [(1S)-1-formyl-2-methylbutyl]-, 1,1-dimethylethyl ester (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [(1S)-1-formyl-2-methylbutyl]-, 1,1-dimethylethyl ester (9CI)(254888-05-6)
• EPA Substance Registry System: Carbamic acid, [(1S)-1-formyl-2-methylbutyl]-, 1,1-dimethylethyl ester (9CI)(254888-05-6)

Safety Data

• Hazardous Substances Data: 254888-05-6(Hazardous Substances Data)

Upstream product

• 13139-16-7 N-tert-butyloxy-isoleucine 
• 87694-51-7 N^α-(t-butoxycarbonyl)-L-isoleucine N-methoxy-N-methylamide 
• 545433-88-3 N-(tert-butyloxycarbonyl)-L-isoleucinol 
• 1026362-25-3 2-tert-butoxycarbonylamino-3-methyl-pentanoic acid 4,6-dimethoxy-[1,3,5]triazin-2-yl ester 

Downstream Products

• 1026801-45-5 N-<2(S)-<<(tert-butoxycarbonyl)-S-(triphenylmethyl)cysteinyl>amino>-3-methylpentyl>isoleucylhomoserine lactone 

Relevant articles and documents

A simple method for the reduction of carboxylic acids to aldehydes or alcohols using H2 and Pd/C

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The Influence of Protecting Group Character on the Diastereoselectivity of Thiazolidine Ring Formation from Amino Aldehydes and Cysteine

A series of 2-(1'-aminoalkyl)-thiazolidine-4-carboxylic acid derivatives was synthesized by condensation of (R)- or (S)-Cys with the amino aldehydes obtained from N-Boc-protected (S)-Ile, (S)-Leu, O-Bzl-(S)-Tyr, (S)- and (R)-Phe, and N-Z-(S)-Phe, N-Pht-(S)-Phe and N-(Pht)-(R)-Phe. All compounds were studied by 1H NMR and CD. The 2D NOESY experiments were carried out to determine the configuration of the newly formed stereogenic centre in position 2 of the thiazolidine ring. It was found that the configuration on the thiazolidine C2 atom is R or S when N-Boc- and N-Z-(S)-amino aldehydes or N-Boc- and N-Z-(R)-amino aldehydes are used in the reaction, respectively. The situation is opposite in the case of N-Pht-Phe derived amino aldehydes. The relation between the C2 atom configuration and the shape of CD spectra is discussed. Key words: 2-(1'-aminoalkyl)-thiazolidine-4-carboxylic acids, amino aldehydes, cysteine, stereoselectivity, absolute configuration, NMR, CD.

Renin inhibitors containing statine or derivatives thereof

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