254892-91-6

Basic information

• Product Name: 3-(4-bromophenyl)cyclobutanone
• Synonyms: 3-(4-bromophenyl)cyclobutanone;Cyclobutanone, 3-(4-bromophenyl)-
• CAS NO: 254892-91-6
• Molecular Formula: C₁₀H₉BrO
• Molecular Weight: 225
• Mol File: 254892-91-6.mol
• Article Data: 25

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-(4-bromophenyl)cyclobutanone(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-bromophenyl)cyclobutanone(254892-91-6)
• EPA Substance Registry System: 3-(4-bromophenyl)cyclobutanone(254892-91-6)

Safety Data

• Hazardous Substances Data: 254892-91-6(Hazardous Substances Data)

Usage

Description

3-(4-bromophenyl)cyclobutanone is an organic compound characterized by its cyclobutanone core with a bromophenyl group attached at the 3-position. This molecule is known for its unique structural properties and potential applications in various fields.

Uses

Used in Pharmaceutical Industry:
3-(4-bromophenyl)cyclobutanone is used as a key intermediate in the synthesis of selective T-type calcium channel blockers. These blockers play a crucial role in the treatment of various cardiovascular and neurological disorders by modulating the flow of calcium ions through T-type calcium channels, which are essential for the proper functioning of the heart and nervous system.

Upstream product

• 254892-87-0 3-(4-bromophenyl)-2,2-dichlorocyclobutan-1-one 
• 2039-82-9 1-bromo-4-ethenyl-benzene 
• 127-19-5 N,N-dimethyl acetamide 
• 463-51-4 Ketene 
• 1122-91-4 4-bromo-benzaldehyde 
• 107-06-2 1,2-dichloro-ethane 

Downstream Products

• 254892-95-0 3-(4-bromophenyl)cyclobutanone ethylene ketal 
• 254892-82-5 1-amino-3-(4-dihydroxyborylphenyl)cyclobutanecarboxylic acid 
• 254893-03-3 3-(4-boronophenyl)cyclobutanone 
• 254892-99-4 3-(4-boronophenyl)cyclobutanone ethylene ketal 
• 254893-07-7 C₁₂H₁₃BN₂O₄ 
• 1033082-32-4 (-)-(R)-4-(4-bromophenyl)dihydrofuran-2(3H)-one 
• 1019842-34-2 1-(1-benzyloxy-propa-1,2-dienyl)-3-(4-bromo-phenyl)-cyclobutanol 
• 1183047-51-9 3-(4-bromophenyl)cyclobutanol 
• 1236357-60-0 1-bromo-4-(3,3-difluorocyclobutyl)benzene 
• 1245831-62-2 3-(4-bromophenyl)-1-cyclopropylcyclobutanol 
• 1329607-69-3 C₁₆H₁₇BrO₂ 
• 1329607-70-6 C₁₆H₁₇BrO₂ 

Relevant articles and documents

PROCESSES FOR PREPARING TRIAZOLE GLYCOLATE OXIDASE INHIBITORS

The present disclosure provides processes for preparing 1,2,3-triazole-4-carboxylic acid related compounds of formulae (I) and (II) via a Suzuki coupling reaction. The Suzuki coupling reaction is achieved by coupling a compound of formula (IV), a boron-containing derivative of 1,2,3-triazole-4-carboxylate, with a cycloalkyl phenyl halide or sulfonate of formula (V).

Desymmetrization of Prochiral Cyclobutanones via Nitrogen Insertion: A Concise Route to Chiral γ-Lactams

Asymmetric access to γ-lactams is achieved via a cyclobutanone ring expansion using widely available (1S,2R)-1-amino-2-indanol for chiral induction. Mechanistic analysis of the key N,O-ketal rearrangement reveals a Curtin–Hammett scenario, which enables a downstream stereoinduction (up to 88:12 dr) and is corroborated by spectroscopic, crystallographic, and computational studies. In combination with an easy deprotection protocol, this operationally simple sequence allows the synthesis of a range of optically pure γ-lactams, including those bearing all-carbon quaternary stereocenters. In addition, the formal synthesis of drug molecules baclofen, brivaracetam, and pregabalin further demonstrates the synthetic utility and highlights the general applicability of the presented method.

Metal-free chalcogenation of cycloketone oxime esters with dichalcogenides

We report the metal-free chalcogenation of cycloketone oxime esters with dichalcogenides via a radical process. Because of the metal-free condition and use of readily accessible dichalcogenides, this method is an effective and green strategy for the synthesis of chalcogen-substituted butyronitrile.