2549-19-1 Usage
Description
2-Methyl-imidazo[1,2-a]pyridine-3-carboxylic acid ethyl ester, also known as Ethyl 2-Methylimidazo[1,2-a]pyridine-3-carboxylate, is an organic compound with a light yellow to brown solid appearance. It is characterized by its unique chemical structure, which contributes to its various applications in the field of chemistry and pharmaceuticals.
Uses
Used in Chemical Synthesis:
2-Methyl-imidazo[1,2-a]pyridine-3-carboxylic acid ethyl ester is used as a synthetic intermediate for the preparation of β-hydroxy carbonyl compounds and α,β-unsaturated carbonyl compounds. Its unique structure allows for the creation of a wide range of chemical products, making it a valuable compound in the field of organic chemistry.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-Methyl-imidazo[1,2-a]pyridine-3-carboxylic acid ethyl ester is utilized as a key component in the development of various drugs. Its versatility in chemical synthesis enables the creation of new drug candidates with potential therapeutic applications.
Used in Research and Development:
2-Methyl-imidazo[1,2-a]pyridine-3-carboxylic acid ethyl ester is also employed in research and development settings, where it is used to study the properties and reactions of similar compounds. This helps scientists and researchers to better understand the behavior of these molecules and develop new strategies for their application in various industries.
Synthesis Reference(s)
The Journal of Organic Chemistry, 30, p. 2403, 1965 DOI: 10.1021/jo01018a071
Check Digit Verification of cas no
The CAS Registry Mumber 2549-19-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,5,4 and 9 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 2549-19:
(6*2)+(5*5)+(4*4)+(3*9)+(2*1)+(1*9)=91
91 % 10 = 1
So 2549-19-1 is a valid CAS Registry Number.
2549-19-1Relevant articles and documents
Synthesis and biological evaluation of new imidazo[1,2-a]pyridine derivatives designed as mefloquine analogues.
Lima, Patricia C,Avery, Mitchell A,Tekwani, Babu L,de Alves, Helio M,Barreiro, Eliezer J,Fraga, Carlos A M
, p. 825 - 832 (2002)
This paper describes the synthesis and the in vitro antimalarial profile of two new imidazo[1,2-a]pyridine derivatives 4HCl and 13HCl, structurally proposed as mefloquine (1) analogues, by exploring bioisosterism and molecular simplification tools. The synthetic route employed to access the title compounds used, as starting material, the previously described ethyl 2-methylimidazo[1,2-aJpyridine-3-carboxylate derivative (5). These novel heterocyclic derivatives 4HCl and 13HCl presented modest antimalarial activity against the W-2 and D-6 clones of Plasmodium falciparum as well as inhibitors of in vitro heme polymerization compared to mefloquine.
NBS mediated protocol for the synthesis of N-bridged fused heterocycles in water
Bhagat, Saket B.,Telvekar, Vikas N.
, p. 3662 - 3666 (2017/08/23)
A facile and environmental friendly protocol for the synthesis of N-bridged fused bicyclic compounds such as imidazo[1,2-a]pyridines, imidazo[1,2-a]pyrimidines, and imidazo[2,1-b]thiazole, from commercially available starting materials has been developed.
CBr4 Mediated Oxidative C-N Bond Formation: Applied in the Synthesis of Imidazo[1,2-α]pyridines and Imidazo[1,2-α]pyrimidines
Huo, Congde,Tang, Jing,Xie, Haisheng,Wang, Yajun,Dong, Jie
supporting information, p. 1016 - 1019 (2016/03/15)
The carbon tetrabromide mediated oxidative carbon-nitrogen bond formation of 2-aminopyridines or 2-aminopyrimidines with β-keto esters or 1,3-diones, leading to a variety of complex imidazo[1,2-α]pyridines or imidazo[1,2-α]pyrimidines, is reported. The re