254975-86-5

Basic information

• Product Name: (R)-(-)-3-[2-(Benzyloxy)-5-bromophenylacetyl]-4-isopropyloxazolidin-2-one
• Synonyms: (R)-(-)-3-[2-(Benzyloxy)-5-bromophenylacetyl]-4-isopropyloxazolidin-2-one
• CAS NO: 254975-86-5
• Molecular Weight: 432.314
• Mol File: 254975-86-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (R)-(-)-3-[2-(Benzyloxy)-5-bromophenylacetyl]-4-isopropyloxazolidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(-)-3-[2-(Benzyloxy)-5-bromophenylacetyl]-4-isopropyloxazolidin-2-one(254975-86-5)
• EPA Substance Registry System: (R)-(-)-3-[2-(Benzyloxy)-5-bromophenylacetyl]-4-isopropyloxazolidin-2-one(254975-86-5)

Safety Data

• Hazardous Substances Data: 254975-86-5(Hazardous Substances Data)

Upstream product

• 149428-97-7 2-(Benzyloxy)-5-bromophenylacetic acid 
• 95530-58-8 (R)-4-isopropyloxazolidin-2-one 

Downstream Products

• 254975-92-3 (2R,3R)-(-)-5-{(1S)-1-[(1R)-N-Benzyl-1-phenylethylamino]-2-(tert-butoxycarbonyl)ethyl}-2-(3,4-dimethoxyphenyl)-2,3-dihydrobenzofuran-3-carboxylic acid 
• 254975-88-7 (4R)-(-)-3-{[(2R,3R)-5-Bromo-2-(3,4-dimethoxyphenyl)-2,3-dihydrobenzofuran-3-yl]carbonyl}-4-isopropyloxazolidin-2-one 
• 254975-91-2 (2R,3R)-(-)-5-[2-(tert-Butoxycarbonyl)vinyl]-2-(3,4-dimethoxyphenyl)-2,3-dihydrobenzofuran-3-carboxylic acid 
• 254975-90-1 (-)-Methyl (2R,3R)-5-[2-(tert-butoxycarbonyl)vinyl]-2-(3,4-dimethoxyphenyl)-2,3-dihydrobenzofuran-3-carboxylate 
• 254975-89-8 (-)-Methyl (2R,3R)-5-bromo-2-(3,4-dimethoxyphenyl)-2,3-dihydrobenzofuran-3-carboxylate 
• 254975-87-6 (4R)-(+)-3-{(2R,3R)-2-[2-(Benzyloxy)-5-bromophenyl]-3-(3,4-dimethoxyphenyl)-3-hydroxypropanoyl}-4-isopropyloxazolidin-2-one 

Relevant articles and documents

Asymmetric synthesis of the northern segment of ephedradine C

An asymmetric synthesis of the dihydrobenzofuran segment of ephedradine C has been achieved. Key steps include a chiral oxazolidinone-mediated aldol reaction to form a β-hydroxy ester, followed by a novel debenzylation and concomitant intramolecular cyclisation with iodotrimethylsilane. An asymmetric Michael reaction with a homochiral lithium amide was used to form the third and final chiral centre. The absolute stereochemistry of these three centres was confirmed by X-ray crystal-structure determinations.