25507-04-4

Basic information

• Product Name: Clindamycin palmitate hydrochloride
• Synonyms: clindamycin2’-palmitatehydrochloride;Clindmycin;Methyl7-chloro-6,7,8-trideoxy-6-(1-methyl-trans-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-L-threo-alpha-D-galacto-octopyranoside2-hexadecanoatemonohydrochloride;Clindamycin palmitate hydrochloride;Clindamycin Hydrochloride Palmitate;Clindamycin Palmitate Hydrochloride (500 mg);Clindamycin Palmitate Hydrochloride (500 mg)G0D334586ug/mg(an);ClindaMycin PalMitate HCl USP
• CAS NO: 25507-04-4
• Molecular Formula: C₃₄H₆₃ClN₂O₆S*ClH
• Molecular Weight: 699.85
• EINECS: 1312995-182-4
• Product Categories: PHENYPASTEBAMIN;Inhibitors
• Mol File: 25507-04-4.mol
• Article Data: 0

Chemical Properties

• Melting Point: 141-143°C
• Boiling Point: 767.4 °C at 760 mmHg
• Flash Point: 417.9 °C
• Appearance: /
• Vapor Pressure: 3.44E-27mmHg at 25°C
• Storage Temp.: -20°C Freezer, Under Inert Atmosphere
• Solubility: DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: Clindamycin palmitate hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: Clindamycin palmitate hydrochloride(25507-04-4)
• EPA Substance Registry System: Clindamycin palmitate hydrochloride(25507-04-4)

Safety Data

• Hazardous Substances Data: 25507-04-4(Hazardous Substances Data)

Usage

Description

Clindamycin palmitate hydrochloride, also known as Cleocin Pediatric, is a water-soluble prodrug form of the antibiotic clindamycin. It is the hydrochloride salt of the palmitic acid ester of cleomycin, with the ester bond attached to the 2-hydroxyl group of the lincosamine sugar. This ester serves as a tasteless prodrug form, which hydrolyzes to clindamycin in the plasma. The salt form confers water solubility to the ester, making it suitable for pediatric use. Clindamycin palmitate hydrochloride is a white solid and is marketed under the brand name Cleocin by Pharmacia & Upjohn.

Uses

Used in Pharmaceutical Industry:
Clindamycin palmitate hydrochloride is used as an antibacterial agent for the treatment of various bacterial infections. It is particularly effective as a tuberculostatic, helping to combat tuberculosis.
Used in Pediatric Medicine:
Clindamycin palmitate hydrochloride is used as a tasteless prodrug form for pediatric use, making it more palatable for children. The ester hydrolyzes in the plasma to release the active clindamycin, ensuring effective treatment with minimal discomfort.
Used in Drug Formulation:
Clindamycin palmitate hydrochloride is used in the formulation of oral solutions, granules, and other pharmaceutical products. Its water solubility and stability make it an ideal candidate for various drug delivery systems.
Used in Antimicrobial Therapy:
Clindamycin palmitate hydrochloride is used as an antimicrobial agent in the treatment of bacterial infections, offering high bioavailability and rapid hydrolysis in vivo to release the active clindamycin.

InChI:InChI=1/C34H63ClN2O6S.ClH/c1-6-8-9-10-11-12-13-14-15-16-17-18-19-21-27(38)42-32-30(40)29(39)31(43-34(32)44-5)28(24(3)35)36-33(41)26-22-25(20-7-2)23-37(26)4;/h24-26,28-32,34,39-40H,6-23H2,1-5H3,(H,36,41);1H/t24-,25+,26-,28+,29+,30-,31+,32+,34+;/m0./s1