25508-19-4

Basic information

• Product Name: N-benzyloxycarbonyl-S-methyl-isothiourea
• Synonyms: N-benzyloxycarbonyl-S-methyl-isothiourea
• CAS NO: 25508-19-4
• Molecular Weight: 224.283
• Mol File: 25508-19-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-benzyloxycarbonyl-S-methyl-isothiourea(CAS DataBase Reference)
• NIST Chemistry Reference: N-benzyloxycarbonyl-S-methyl-isothiourea(25508-19-4)
• EPA Substance Registry System: N-benzyloxycarbonyl-S-methyl-isothiourea(25508-19-4)

Safety Data

• Hazardous Substances Data: 25508-19-4(Hazardous Substances Data)

Upstream product

• 53114-57-1 S-methylisothiourea hydrochloride 
• 501-53-1 benzyl chloroformate 
• 867-44-7 S-Methylisothiourea sulfate 
• 2986-19-8 carbamimidothioic acid methyl ester 

Downstream Products

• 1218915-84-4 1-benzyloxycarbonyl-3-(4-methoxy-benzoyl)-2-methyl-isothiourea 
• 1282529-47-8 [5-(8-bromo-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulen-2-yl)-1-isopropyl-1H-[1,2,4]triazol-3-yl]-carbamic acid benzyl ester 
• 198416-09-0 C₄₉H₅₉N₉O₁₂ 
• 198416-10-3 C₄₅H₅₁N₉O₁₂ 
• 169808-24-6 {2-[4-(R,S)-(4-benzyloxycarbonyl-guanidino-phenyl)-4-methyl-2,5-dioxo-imidazolidin-1-yl]acetyl}-Asp(O-t-Bu)-(S)-phenylglycine-O-t-Bu 
• 169808-28-0 [4-(R,S)-(4-benzyloxycarbonylguanidino-phenyl)-4-methyl-2,5-dioxo-imidazolidin-1-yl]acetic acid 
• 340188-35-4 (R,S)-(3-ethoxycarbonylmethyl-ureido)-(4-benzyloxycarbonyl-guanidino-phenyl)acetic acid methyl ester 
• 169808-27-9 [4-(R,S)-(4-benzyloxycarbonylguanidino-phenyl)-4-methyl-2,5-dioxo-imidazolidin-1-yl]acetic acid methyl ester 
• 176106-49-3 N-(benzyloxycarbonyl)ureido-N'-(benzyloxycarbonyl)-(S)-methylisothiourea 

Relevant articles and documents

Mimicking of Arginine by Functionalized Nω-Carbamoylated Arginine As a New Broadly Applicable Approach to Labeled Bioactive Peptides: High Affinity Angiotensin, Neuropeptide Y, Neuropeptide FF, and Neurotensin Receptor Ligands As Examples

Derivatization of biologically active peptides by conjugation with fluorophores or radionuclide-bearing moieties is an effective and commonly used approach to prepare molecular tools and diagnostic agents. Whereas lysine, cysteine, and N-terminal amino acids have been mostly used for peptide conjugation, we describe a new, widely applicable approach to peptide conjugation based on the nonclassical bioisosteric replacement of the guanidine group in arginine by a functionalized carbamoylguanidine moiety. Four arginine-containing peptide receptor ligands (angiotensin II, neurotensin(8-13), an analogue of the C-terminal pentapeptide of neuropeptide Y, and a neuropeptide FF analogue) were subject of this proof-of-concept study. The Nω-carbamoylated arginines, bearing spacers with a terminal amino group, were incorporated into the peptides by standard Fmoc solid phase peptide synthesis. The synthesized chemically stable peptide derivatives showed high receptor affinities with Ki values in the low nanomolar range, even when bulky fluorophores had been attached. Two new tritiated tracers for angiotensin and neurotensin receptors are described.

Novel anticoagulant agmatine derivatives and process for the preparation thereof

Anti-coagulants of the formula X-Pro-Agm(HB) (n) wherein X is an alpha-amino acid moiety of the configuration having a phenyl, phenyl-(lower)-alkyl or phenyl-(heteroatom-containing) lower alkyl side chain, Agm is an agmatine group (1-am