25509-06-2

Basic information

• Product Name: 3-(2,6-dichlorophenyl)-2-methylquinazolin-4(3H)-one
• Synonyms: 3-(2,6-Dichloro-phenyl)-2-methyl-3H-quinazolin-4-one; 4(3H)-Quinazolinone, 3-(2,6-dichlorophenyl)-2-methyl-; Quinazolin-4(3H)-one, 3-(2,6-dichlorophenyl)-2-methyl-
• CAS NO: 25509-06-2
• Molecular Formula: C₁₅H₁₀Cl₂N₂O
• Molecular Weight: 305.1587
• Mol File: 25509-06-2.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 444.8°C at 760 mmHg
• Flash Point: 222.8°C
• Density: 1.39g/cm³
• Vapor Pressure: 4.16E-08mmHg at 25°C
• Refractive Index: 1.66
• CAS DataBase Reference: 3-(2,6-dichlorophenyl)-2-methylquinazolin-4(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2,6-dichlorophenyl)-2-methylquinazolin-4(3H)-one(25509-06-2)
• EPA Substance Registry System: 3-(2,6-dichlorophenyl)-2-methylquinazolin-4(3H)-one(25509-06-2)

Safety Data

• Hazardous Substances Data: 25509-06-2(Hazardous Substances Data)

Upstream product

• 608-31-1 2,6-Dichloroaniline 
• 89-52-1 o-acetylamino-benzoic acid 
• 525-76-8 2-methyl-4-oxo-3,1-benzoxazine 
• 118-92-3 anthranilic acid 

Downstream Products

• 123382-23-0 3-(2,6-Dichloro-phenyl)-2-(2-oxo-2-pyridin-4-yl-ethyl)-3H-quinazolin-4-one 
• 96911-44-3 3-(2,6-Dichloro-phenyl)-2-[(E)-2-(4-methoxy-phenyl)-vinyl]-3H-quinazolin-4-one 
• 96911-50-1 2-[1,2-Dibromo-2-(4-methoxy-phenyl)-ethyl]-3-(2,6-dichloro-phenyl)-3H-quinazolin-4-one 

Relevant articles and documents

Atropisomeric quinazolin-4-one derivatives are potent noncompetitive α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonists

Piriqualone (1) was found to be an antagonist of AMPA receptors. Structure-activity optimization was conducted on each of the three rings in 1 to afford a series of potent and selective antagonists. The sterically crowded environment surrounding the N-3 aryl group provided sufficient thermal stability for atropisomers to be isolated. Separation of these atropisomers resulted in the identification of (+)-38 (CP-465,022), a compound that binds to the AMPA receptor with high affinity (IC50 = 36 nM) and displays potent anticonvulsant activity.