25514-13-0

Basic information

• Product Name: 2(1H)-Quinazolinone, 6-chloro-3,4-dihydro-4-hydroxy-3,4-diphenyl-
• CAS NO: 25514-13-0
• Molecular Formula: C20H15ClN2O2
• Molecular Weight: 350.804
• Mol File: 25514-13-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2(1H)-Quinazolinone, 6-chloro-3,4-dihydro-4-hydroxy-3,4-diphenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2(1H)-Quinazolinone, 6-chloro-3,4-dihydro-4-hydroxy-3,4-diphenyl-(25514-13-0)
• EPA Substance Registry System: 2(1H)-Quinazolinone, 6-chloro-3,4-dihydro-4-hydroxy-3,4-diphenyl-(25514-13-0)

Safety Data

• Hazardous Substances Data: 25514-13-0(Hazardous Substances Data)

Upstream product

• 719-59-5 5-chloro-2-aminobenzophenone 
• 103-71-9 phenyl isocyanate 
• 5100-23-2 2-isocyanatobenzoyl chloride 
• 62-53-3 aniline 
• 71-43-2 benzene 

Relevant articles and documents

Friedel-Crafts Acylation with 2-Isocyanatobenzoyl Chlorides: The Structure of the Intermediate Complex

The intermediate complex obtained in the Friedel-Crafts acylation of benzene with 2-isocyanatobenzoyl chloride (1a) reacts with methanol or ethanol in the presence of ether affording 4-alkoxy-4-phenyl-1,4-dihydro-3,1-benzoxazin-2(1H)-ones, whereas with anilines, the corresponding anils of 2-aminobenzophenone are obtained.In the presence of triethylamine, the complex reacts with aniline and 2-aminobenzophenone affording 4-hydroxy-4-phenyl-3-substituted 3,4-dihydroquinazolin-2(1H)-ones whereas, with alkyl anthranilates, the new 11b-phenyl-7,11b-dihydroquinazolinobenzoxazine-6,13-diones are obtained.Similar products are also obtained from 5-chloro-2-isocyanatobenzoyl chloride.The intermediate complex has been shown to exist exclusively in the cyclic form in both acidic and basic media.