255376-41-1

Basic information

• Product Name: Benzeneacetic acid, 4-methoxy-2-(methoxycarbonyl)-, methyl ester
• CAS NO: 255376-41-1
• Molecular Formula: C12H14O5
• Molecular Weight: 238.24
• Mol File: 255376-41-1.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Benzeneacetic acid, 4-methoxy-2-(methoxycarbonyl)-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneacetic acid, 4-methoxy-2-(methoxycarbonyl)-, methyl ester(255376-41-1)
• EPA Substance Registry System: Benzeneacetic acid, 4-methoxy-2-(methoxycarbonyl)-, methyl ester(255376-41-1)

Safety Data

• Hazardous Substances Data: 255376-41-1(Hazardous Substances Data)

Upstream product

• 186581-53-3 diazomethane 
• 52962-25-1 2-(carboxymethyl)-5-methoxybenzoic acid 
• 67-56-1 methanol 
• 67755-25-3 2-carboxymethyl-5-hydroxybenzoic acid 
• 77-78-1 dimethyl sulfate 
• 3898-66-6 2-(carboxymethyl)-5-nitrobenzoic acid 
• 22901-69-5 5-amino-2-(carboxymethyl)benzoic acid 
• 4741-63-3 6-methoxyphthalide 
• 76254-25-6 2-cyanomethyl-5-methoxy-benzoic acid 
• 74-88-4 methyl iodide 
• 89-51-0 Homophthalic acid 
• 22921-68-2 2-bromo-5-methoxy-benzoic acid 
• 1370606-52-2 2-(2-carboxy-4-methoxy-phenyl)-malonic acid dimethyl ester 
• 1432752-19-6 2-(2-carboxy-4-methoxy-phenyl)-malonic acid 

Downstream Products

• 1383786-67-1 methyl 2-{1-[(benzyloxy)amino]-3-methoxy-1,3-dioxopropan-2-yl}-5-methoxybenzoate 
• 1432752-40-3 2-(2-dimethylamino-1-methoxycarbonyl-vinyl)-5-methoxy-benzoic acid methyl ester 
• 52962-25-1 2-(carboxymethyl)-5-methoxybenzoic acid 
• 4702-29-8 7-methoxy-1H-isochromene-1,3(4H)-dione 
• 1609575-79-2 C₁₃H₁₄O₇ 
• 1383785-73-6 N-(4-fluorobenzyl)-2-hydroxy-7-methoxy-1,3-dioxo-1,2,3,4-tetrahydroisoquinoline-4-carboxamide 
• 1383786-69-3 N-(4-fluorobenzyl)-2-(benzyloxy)-7-methoxy-1,3-dioxo-1,2,3,4-tetrahydroisoquinoline-4-carboxamide 
• 1383786-68-2 methyl 2-(benzyloxy)-7-methoxy-1,3-dioxo-1,2,3,4-tetrahydroisoquinoline-4-carboxylate 
• 916168-40-6 [4-methoxy-2-(methoxycarbonyl)phenyl]acetic acid 
• 1355049-01-2 methyl 2-(2-chloro-2-oxoethyl)-5-methoxybenzoate 
• 1355049-14-7 6-methoxy-1-oxo-N-phenyl-1,3-dihydro-2H-isoindole-2-carboxamide 
• 1355049-10-3 methyl 2-{[(anilinocarbonyl)amino]methyl}-5-methoxybenzoate 
• 1355049-07-8 methyl 5-methoxy-2-{[(methoxycarbonyl)amino]methyl}benzoate 
• 1355049-04-5 methyl 2-(2-azido-2-oxoethyl)-5-methoxybenzoate 

Relevant articles and documents

Design, synthesis and biological evaluation of 3-substituted indenoisoquinoline derivatives as topoisomerase I inhibitors

A new series of indenoisoquinoline derivatives was designed and synthesized. The in vitro anti-proliferative activity of these novel compounds was evaluated in HepG2, A549 and HCT-116 cell lines. Compounds 9a, 9b, 10a, 10c, 10e, 18a and 18b manifested potent inhibitory activity against the three tested cancer cell lines. Nineteen compounds were also tested for Top I inhibition at 50 μM. Almost all the tested compounds showed potent Top I inhibition activity at this concentration. The most potent compounds 9a and 10a demonstrated more cytotoxicity than HCPT and TPT and was comparable to CPT in inhibitory activities on Top I in our biological assay.

NOVEL INHIBITOR COMPOUNDS OF PHOSPHODIESTERASE TYPE 10A

The present invention relates to compounds which are inhibitors of phosphodiesterase type 10A and to their use for the manufacture of a medicament and which thus are suitable for treating or controlling of medical disorders selected from neurological diso

Synthesis of indolin-2-one, isoindolin-1-one, and indole derivatives from homophthalic acid

We hereby report the preparation of indolin-2-one and isoindolin-1-one and their derivatives starting from 2-(carboxymethyl)benzoic acid, which was first regiospecifically converted into the isomeric half esters. Transformation of the acid functionalities to the acyl azides followed by Curtius rearrangement gave the regioisomeric isocyanates. Reaction of the isocyanates with aniline produced urethane derivatives. Intramolecular cyclization provided the target compounds. Georg Thieme Verlag Stuttgart. New York.