255730-31-5

Basic information

• Product Name: 10α-(4-benzylpiperazin-1-yl)-10-deoxoartemisinin
• Synonyms: 10α-(4-benzylpiperazin-1-yl)-10-deoxoartemisinin
• CAS NO: 255730-31-5
• Molecular Weight: 442.599
• Mol File: 255730-31-5.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 10α-(4-benzylpiperazin-1-yl)-10-deoxoartemisinin(CAS DataBase Reference)
• NIST Chemistry Reference: 10α-(4-benzylpiperazin-1-yl)-10-deoxoartemisinin(255730-31-5)
• EPA Substance Registry System: 10α-(4-benzylpiperazin-1-yl)-10-deoxoartemisinin(255730-31-5)

Safety Data

• Hazardous Substances Data: 255730-31-5(Hazardous Substances Data)

Upstream product

• 2759-28-6 1-phenylmethylpiperazine 
• 887195-43-9 C₁₅H₂₃BrO₄ 
• 140658-34-0 10β-(trimethylsilyloxy)dihydroartemisinin 
• 255731-10-3 10α-(trimethylsilyloxy)dihydroartemisinin 
• 71939-50-9 dihydroartemisinin 
• 81496-81-3 dihydroartesiminin 

Downstream Products

• 71939-50-9 dihydroartemisinin 
• 1093625-96-7 (R)-2-[(3S,4R)-4-Methyl-2-oxo-3-(3-oxo-butyl)-cyclohexyl]-propionaldehyde 

Relevant articles and documents

Artemisone - A highly active antimalarial drug of the artemisinin class

Artemisinin - the next generation: Efficacies of artemisone against the malaria parasite are substantially greater than those of the current artemisinin "gold standard", artesunate. Also, in contrast to most current artemisinins it displays low lipophilic

C1O-modified artemisinin derivatives: Efficient heme-alkylating agents

(Chemical Equation Presented) Discussion is reopened regarding C10-substituted derivatives of the peroxide-based antimalarial agent artemisinin (see picture); they are shown to react readily with iron(II)-heme to provide heme-drug adducts in high yields.