25574-19-0

Basic information

• Product Name: Benzenemethanol, 4-bromo-a-(2-chloroethyl)-
• Synonyms: 1-(4-bromo-phenyl)-3-chloro-propan-1-ol;1-(4-bromo-phenyl)-3-chloro-propan--ol;3-Chlor-1-(4-bromphenyl)-1-propanol
• CAS NO: 25574-19-0
• Molecular Formula: C9H10BrClO
• Molecular Weight: 249.535
• Mol File: 25574-19-0.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 132 - 133 °C (0.1 mmHg)
• CAS DataBase Reference: Benzenemethanol, 4-bromo-a-(2-chloroethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanol, 4-bromo-a-(2-chloroethyl)-(25574-19-0)
• EPA Substance Registry System: Benzenemethanol, 4-bromo-a-(2-chloroethyl)-(25574-19-0)

Safety Data

• Hazardous Substances Data: 25574-19-0(Hazardous Substances Data)

Upstream product

• 31736-73-9 4-bromophenyl 2-chloroethyl ketone 

Downstream Products

• 25574-16-7 2-(4-bromophenyl)oxetane 
• 1309576-59-7 1-(4-bromophenyl)-1,3-dichloropropane 
• 1542817-48-0 [3-chloro-2-(1-methylazetidin-2-yl)phenyl]diphenylmethanol 
• 1542817-46-8 2-(2-chloro-6-methylphenyl)-1-methylazetidine 
• 1542817-03-7 1-methyl-2-(o-tolyl)azetidine 
• 1542817-41-3 1-methyl-2-[2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]azetidine 
• 1542817-27-5 [2-(1-methylazetidin-2-yl)phenyl]diphenylmethanol 
• 1542817-21-9 1-methyl-2-[2-(methyldiphenylsilyl)phenyl]azetidine 
• 1542817-14-0 2-(2-bromophenyl)-1-methylazetidine 
• 1542817-12-8 2-(2-chlorophenyl)-1-methylazetidine 

Relevant articles and documents

AZAINDOLE DERIVATIVE HAVING AMPK-ACTIVATING EFFECT

Disclosed is a compound which is useful as an AMPK activator. A compound represented by formula: or its pharmaceutically acceptable salt, wherein X is substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, or substituted or unsubstituted heterocyclyl; R1 is hydrogen, halogen, cyano, nitro, carboxy, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted acyl, substituted or unsubstituted carbamoyl, substituted or unsubstituted alkylthio, substituted or unsubstituted alkylsulfinyl, substituted or unsubstituted alkylsulfonyl, or substituted or unsubstituted alkyloxycarbonyl; R2 is halogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted heterocyclyl, or the like; R3 is halogen, hydroxy, cyano, nitro, carboxy, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted heterocyclyl, or the like; and R4 is hydrogen, halogen, hydroxy, cyano, nitro, carboxy, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, or the like.

PHARMACEUTICAL COMPOUNDS

The invention provides compounds of the formula (I) having ROCK kinase and/or protein kinase p70S6K inhibiting activity: wherein A is a saturated hydrocarbon linker group containing from 1 to 7 carbon atoms, the linker group having a maximum chain length

Synthesis and biological evaluation of N-[4-(2-trans-[([2,6-diamino-4(3H)-oxopyrimidin-5-yl]methyl)thio]cyclo butyl)benzoyl]-L-glutamic acid a novel 5-thiepyrimidinone inhibitor of dihydrofolate reductase

The synthesis and biological evaluation of N-[4-(2-trans-[([2,6-diamino-4(3H)-oxopyrimidin-5-yl]methyl)thio]cyclo butyl)benzoyl]-L-glutamic acid (1) is reported. Compound 1 is a potent dihydrofolate reductase (DHFR) inhibitor (K(i) = 12 nM) with excellent