255870-01-0

Basic information

• Product Name: 1-benzyl-3,3-bis(4-hydroxyphenyl)indolin-2-one
• Synonyms: 1-benzyl-3,3-bis(4-hydroxyphenyl)indolin-2-one
• CAS NO: 255870-01-0
• Molecular Weight: 407.469
• Mol File: 255870-01-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-benzyl-3,3-bis(4-hydroxyphenyl)indolin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-benzyl-3,3-bis(4-hydroxyphenyl)indolin-2-one(255870-01-0)
• EPA Substance Registry System: 1-benzyl-3,3-bis(4-hydroxyphenyl)indolin-2-one(255870-01-0)

Safety Data

• Hazardous Substances Data: 255870-01-0(Hazardous Substances Data)

Upstream product

• 100-44-7 benzyl chloride 
• 100-39-0 benzyl bromide 
• 91-56-5 indole-2,3-dione 
• 1217-89-6 1-benzylisatin 
• 108-95-2 phenol 

Relevant articles and documents

Lambert Salt-Initiated Development of Friedel–Crafts Reaction on Isatin to Access Distinct Derivatives of Oxindoles

Herein, a mild metal-free and efficacious route for the synthesis of biologically important 3-aryl oxindole derivatives is described. Using Lambert salt-initiated hydroarylation of isatin, a diverse array of monoarylated products, symmetrical/unsymmetrical double-arylated products, and deoxygenated hydroarylated products could be synthesized from the single starting substrate in good to excellent yields. A preliminary mechanistic study revealed that the reaction proceeds via a monoarylated product followed by a nucleophilic attack by another electron-rich arene nucleophile under mild conditions. The potential of newly synthesized symmetric/unsymmetric 3,3-disubstituted oxindole, 3-substituted 3-hydroxy oxindoles, 3,3-di(indolyl)indolin-2-ones, and α-aryl oxindoles as valuable building blocks is further illustrated.