255876-61-0

Basic information

• Product Name: Ethanimidamide, 2-chloro-N-[[3-(trifluoromethyl)benzoyl]oxy]-
• CAS NO: 255876-61-0
• Molecular Formula: C10H8ClF3N2O2
• Molecular Weight: 280.634
• Mol File: 255876-61-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Ethanimidamide, 2-chloro-N-[[3-(trifluoromethyl)benzoyl]oxy]-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanimidamide, 2-chloro-N-[[3-(trifluoromethyl)benzoyl]oxy]-(255876-61-0)
• EPA Substance Registry System: Ethanimidamide, 2-chloro-N-[[3-(trifluoromethyl)benzoyl]oxy]-(255876-61-0)

Safety Data

• Hazardous Substances Data: 255876-61-0(Hazardous Substances Data)

Upstream product

• 2251-65-2 3-(Trifluoromethyl)benzoyl chloride 
• 3272-96-6 2-chloro-N'-hydroxyacetimidamide 
• 3272-96-6 (Z)-2-chloro-N'-hydroxyethanimidamide 

Downstream Products

• 175205-63-7 3-(chloromethyl)-5-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazole 

Relevant articles and documents

Novel 1,3-dipropyl-8-(1-heteroarylmethyl-1H-pyrazol-4-yl)-xanthine derivatives as high affinity and selective A2B adenosine receptor antagonists

A series of new 1,3-dipropyl-8-(1-heteroarylmethyl-1H-pyrazol-4-yl)- xanthine derivatives as A2B-AdoR antagonists have been synthesized and evaluated for their binding affinities for the A2B, A 1, A2A, and A3-AdoRs. 8-(1-((3-phenyl-1,2,4- oxadiazol-5-yl)methyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione (4) displayed high affinity (Ki = 1 nM) and selectivity for the A2B-AdoR versus A1, A2A, and A 3-AdoRs (A1/A2B, A2A/A2B, and A3/A2B selectivity ratios of 370, 1100, and 480, respectively). The synthesis and SAR of this novel class of compounds are presented herein.