255893-57-3

Basic information

• Product Name: 1-(3,4-Difluorophenyl)piperazine
• Synonyms: 1-(3,4-Difluorophenyl)piperazine97%;1-(3,4-Difluorophenyl)piperazine;Piperazine,1-(3,4-difluorophenyl)-
• CAS NO: 255893-57-3
• Molecular Formula: C₁₀H₁₂F₂N₂
• Molecular Weight: 198.21
• Mol File: 255893-57-3.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 107-110
• Flash Point: 141.9 °C
• Appearance: /
• Density: 1.193 g/cm³
• Vapor Pressure: 0.000579mmHg at 25°C
• Refractive Index: 1.511
• CAS DataBase Reference: 1-(3,4-Difluorophenyl)piperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3,4-Difluorophenyl)piperazine(255893-57-3)
• EPA Substance Registry System: 1-(3,4-Difluorophenyl)piperazine(255893-57-3)

Safety Data

• Hazard Codes: C
• Hazardous Substances Data: 255893-57-3(Hazardous Substances Data)

Usage

General Description

1-(3,4-Difluorophenyl)piperazine is a chemical compound with the molecular formula C10H12F2N2. It is a piperazine derivative that contains a fluorine-substituted phenyl ring. 1-(3,4-Difluorophenyl)piperazine has been studied for its potential pharmacological properties, including its activity as a serotonin receptor agonist and its potential as a treatment for various medical conditions. It has also been investigated as a precursor in the synthesis of other pharmaceutical compounds. Due to its chemical structure and properties, 1-(3,4-Difluorophenyl)piperazine is of interest in the fields of medicinal chemistry and drug discovery.

InChI:InChI=1/C10H12F2N2/c11-9-2-1-8(7-10(9)12)14-5-3-13-4-6-14/h1-2,7,13H,3-6H2

Upstream product

• 646518-38-9 1-benzyl-4-(3,4-difluorophenyl)-piperazine 
• 110-85-0 piperazine 
• 348-61-8 1-bromo-3,4-difluorobenzene 
• 821-48-7 bis-(2-chloroethyl)amine hydrochloride 
• 3863-11-4 3,4-difluoroaniline 
• 367-23-7 1,2,4-trifluorobenzene 
• 64248-58-4 1,2-difluoro-4-iodo-benzene 

Downstream Products

• 646518-39-0 (4S,4aS,8aR)-4-[4-(3,4-Difluoro-phenyl)-piperazine-1-carbonyl]-octahydro-isoquinoline-2-carboxylic acid tert-butyl ester 
• 946522-90-3 benzyl ester of {2-[4-(3,4-difluorophenyl)piperazin-1-yl]-2-oxoethyl}carbamic acid 
• 362611-66-3 (4S,4aS,8aR)-decahydro-isoquinoline-4-yl-[4-(3,4-difluorophenyl)-piperzin-1-yl]-methanone 
• 1016228-26-4 C₂₆H₂₇ClF₂N₄O 
• 1016228-20-8 C₂₇H₂₉BrF₂N₄O 
• 1016228-19-5 C₂₆H₂₇BrF₂N₄O 
• 1145683-91-5 2-{5-[4-(3,4-difluorophenyl)piperazin-1-yl]-4'-trifluoromethylbiphenyl-3-yl}-4-methylpentanoic acid ethyl ester 
• 524743-90-6 C₁₃H₁₄F₂N₂O 
• 1355155-98-4 2-{3-(4-chlorobenzoyl)-4-[(4-(3,4-difluorophenyl)piperazin-1-yl)methyl]thiophen-2-yl}-isoindole-1,3-dione 
• 1027492-71-2 {2-amino-4-[(4-(3,4-difluorophenyl)piperazin-1-yl)methyl]thiophen-3-yl}(4-chlorophenyl)methanone 

Relevant articles and documents

The development of a practical synthesis of the potent and selective somatostatin sst3 receptor antagonist [4-(3,4-difluoro-phenyl)- piperazine-1-yl]-{(4S,4aS,8aR)-2[(S)-3-(6-methoxy-pyridin-3-yl)-2-methyl-propyl] -decahydroisoquinoline-4-yl}-methanone (NVP-ACQ090)

The decahydroisoquinoline derivative NVP-ACQ090 is a potent and selective antagonist at the somatostatin sst3 receptor. The original research synthesis of NVP-ACQ090 comprises a main chain of nine linear steps and two side chains of three and steps, respectively. This synthesis is highly convergent, but very complex and expensive, and involves several reagents that are not acceptable for a large scale synthesis. In chemical development, all the unacceptables could be replaced, and the overall efficiency of the synthesis was much improved.

Microwave-assisted amination from fluorobenzenes without catalyst and strong base

A facile and versatile amination of fluorobenzenes has been developed in good to excellent yields under microwave irradiation in N-methylpyrrolidinone (NMP) without strong base and catalyst. The presence of additional halogen atom(s) enhanced the leaving ability of fluorine and meta fluorine gave higher activation than the ortho. It is remarkable that 1,2,3-trifluorobenzene, 1,2,4-trifluorobenzene and 1,2,4,5-tetrafluorobenzene can produce the regioselective mono-substituted products.

SUBSTITUTED DIHYDROCHINAZOLINES HAVING ANTIVIRAL PROPERTIES

The invention relates to substituted dihydrochinazolines of formula (I), methods for the production thereof, and the use thereof for producing medicaments used for treating and/or preventing diseases, particularly as antiviral agents, especially against cytomegaloviruses.