256224-02-9

Basic information

• Product Name: 2-AMINO-3'-O-(2-METHOXYETHYL)ADENOSINE
• Synonyms: 2-AMINO-3'-O-(2-METHOXYETHYL)ADENOSINE;3'-O-(2-Methoxyethyl)-2-aminoadenosine
• CAS NO: 256224-02-9
• Molecular Formula: C13H20N6O5
• Molecular Weight: 340.34
• Mol File: 256224-02-9.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 734.5±70.0 °C(Predicted)
• Appearance: /
• Density: 1.81±0.1 g/cm3(Predicted)
• PKA: 12.95±0.70(Predicted)
• CAS DataBase Reference: 2-AMINO-3'-O-(2-METHOXYETHYL)ADENOSINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-3'-O-(2-METHOXYETHYL)ADENOSINE(256224-02-9)
• EPA Substance Registry System: 2-AMINO-3'-O-(2-METHOXYETHYL)ADENOSINE(256224-02-9)

Safety Data

• Hazardous Substances Data: 256224-02-9(Hazardous Substances Data)

Usage

Structure

Modified nucleoside with an adenosine base and a 2-methoxyethyl group attached to the 3' position.

Therapeutic Uses

Anticancer agent
Modulator of immune responses

Research Focus

Regulation of RNA metabolism
Potential target for drug development

Biomedical Applications

Various potential uses in medicine

Ongoing Research

Aimed at elucidating its potential uses and mechanisms of action.

Upstream product

• 16427-44-4 2-methoxyethyl methanesulfonate 
• 2096-10-8 adenosine-2-amine 
• 6482-24-2 2-Bromoethyl methyl ether 
• 620630-82-2 1,2 5,6-O-di(isopropylidene)-α-D-allofuranose 

Relevant articles and documents

An improved process for the manufacture of 5′-O-(4,4′-dimethoxytrityl)-N2-isobutyryl-2′-O-(2-methoxyethyl)guanosine

A revised, optimized process for the manufacture of 5′-O-(4,4′-dimethoxytrityl)-N2-isobutyryl-2′-O-(2- methoxyethyl)guanosine (MOE G PNS) that controls critical impurities to less than 0.2% was developed. The 2′-O-alkylation of 2,6-diaminopurine riboside

Process research on the preparation of DMT protected 2′-O- methoxyethylguanosine for oligonucleotide synthesis in therapeutic applications

An optimized process to synthesize DMT protected 2′-O- methoxyethylguanosine is described. A key step involves the enzymatic deamination of a mixture of alkylated products to selectively afford the desired material without resorting to chromatography for purification. This approach was scaled up to kilogram quantities for use in oligonucleotide therapeutics. Copyright Taylor & Francis Group, LLC.