256328-82-2

Basic information

• Product Name: DESTHIAZOLYLMETHYL RITONAVIR
• Synonyms: DESTHIAZOLYLMETHYL RITONAVIR;(2S)-3-Methyl-2-[[[Methyl[[2-(1-Methylethyl)-4-thiazolyl]Methyl]aMino]carbonyl]aMino]-N-[(1S)-1-[[(4S,5S)-2-oxo-4-(phenylMethyl)-5-oxazolidinyl]Methyl]-2-phenylethyl]-butanaMide;(S)-N-((S)-1-((4S,5S)-4-benzyl-2-oxooxazolidin-5-yl)-3-phenylpropan-2-yl)-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-3-methylbutanamide;RitonavirEP ImpurityL
• CAS NO: 256328-82-2
• Molecular Formula: C₃₃H₄₃N₅O₄S
• Molecular Weight: 605.79062
• Product Categories: Anti-viral Compounds;Anti-virals;Inhibitors;Intermediates & Fine Chemicals;Non-nucleoside Reverse Transcriptase;Pharmaceuticals;Anti-virals, Inhibitors, Non-nucleoside Reverse Transcriptase, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 256328-82-2.mol
• Article Data: 4

Chemical Properties

• Melting Point: 65-69°C
• Boiling Point: 874.007°C at 760 mmHg
• Flash Point: 482.382°C
• Appearance: /
• Density: 1.185g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.578
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly), DMSO (Slightly, Sonicated), Methanol (Slightly)
• PKA: 12.40±0.46(Predicted)
• CAS DataBase Reference: DESTHIAZOLYLMETHYL RITONAVIR(CAS DataBase Reference)
• NIST Chemistry Reference: DESTHIAZOLYLMETHYL RITONAVIR(256328-82-2)
• EPA Substance Registry System: DESTHIAZOLYLMETHYL RITONAVIR(256328-82-2)

Safety Data

• Hazardous Substances Data: 256328-82-2(Hazardous Substances Data)

Usage

Description

DESTHIAZOLYLMETHYL RITONAVIR, also known as Ritonavir EP Impurity L, is an analogue of the selective HIV protease inhibitor Ritonavir (R535000). It is a pharmaceutical compound with potential applications in the treatment of various viral infections, including COVID-19.

Uses

Used in Pharmaceutical Industry:
DESTHIAZOLYLMETHYL RITONAVIR is used as an analogue for the selective HIV protease inhibitor Ritonavir (R535000). It serves as a potential therapeutic agent in the treatment of HIV infections by inhibiting the activity of the viral protease enzyme, which is essential for the replication of the virus.
Used in COVID-19 Research:
DESTHIAZOLYLMETHYL RITONAVIR is used as a COVID-19-related research product. It is being investigated for its potential role in the development of treatments or therapies for COVID-19, the disease caused by the novel coronavirus SARS-CoV-2. As an analogue of Ritonavir, it may offer insights into the development of new antiviral drugs or the repurposing of existing ones for the treatment of COVID-19.

InChI:InChI=1/C33H43N5O4S/c1-21(2)29(37-32(40)38(5)19-26-20-43-31(35-26)22(3)4)30(39)34-25(16-23-12-8-6-9-13-23)18-28-27(36-33(41)42-28)17-24-14-10-7-11-15-24/h6-15,20-22,25,27-29H,16-19H2,1-5H3,(H,34,39)(H,36,41)(H,37,40)/t25-,27-,28-,29-/m0/s1

Upstream product

• 256328-86-6 (4S,5S)-5-((2S)-2-amino-3-phenyl-propyl)-4-benzyl-1,3-oxazolidin-2-one 
• 154212-61-0 N-((N-Methyl-N-((2-isopropyl-4-thiazolyl)methyl)amino)-carbonyl)-L-valine 
• 155213-67-5 ritonavir 

Relevant articles and documents

Application of Isayama–Mukaiyama cobalt catalyzed hydroperoxysilylation for the preparation of ritonavir hydroperoxide

We report the preparation of thiazol-5-ylmethyl ((2S,3S,5S)-5-((S)-2-(3-((2-(2-hydroperoxypropan-2-yl)thiazol-4-yl)methyl)-3-methylureido)-3-methylbutanamido)-3-hydroxy-1,6-diphenylhexan-2-yl)carbamate, a hydroperoxide impurity of ritonavir also known as

Polymorph of a pharmaceutical

A new crystalline polymorph of ritonavir and methods for its use and preparation are disclosed.