2564-57-0

Basic information

• Product Name: 4-carbomethoxy-2-(4-methoxyphenyl)-δ²-thiazoline
• Synonyms: 4-carbomethoxy-2-(4-methoxyphenyl)-δ²-thiazoline
• CAS NO: 2564-57-0
• Molecular Weight: 251.306
• Mol File: 2564-57-0.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 4-carbomethoxy-2-(4-methoxyphenyl)-δ²-thiazoline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-carbomethoxy-2-(4-methoxyphenyl)-δ²-thiazoline(2564-57-0)
• EPA Substance Registry System: 4-carbomethoxy-2-(4-methoxyphenyl)-δ²-thiazoline(2564-57-0)

Safety Data

• Hazardous Substances Data: 2564-57-0(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 52-90-4 L-Cysteine 
• 54998-29-7 ethyl 4-methoxybenzimidate hydrochloride 
• 2485-62-3 L-Cysteine methyl ester 
• 829-48-1 4-methoxy-benzimidic acid ethyl ester 
• 18598-63-5 L-cysteine methyl ester hydrochloride 
• 95064-52-1 methyl 4-methoxybenzimidate 
• 309264-62-8 N-(4-methoxybenzoyl)-S-trityl-L-cysteine methyl ester 
• 1492891-14-1 (R)-2-(4-methoxyphenyl)-4,5-dihydrothiazole-4-carboxylic acid 
• 74-88-4 methyl iodide 
• 123-11-5 4-methoxy-benzaldehyde 
• 874-90-8 4-methoxybenzonitrile 

Downstream Products

• 1315510-08-7 methyl 2-(4-methoxylphenyl)thiazole-4-carboxylate 
• 1315510-23-6 dimethyl 2,2'-di-(4-methoxylphenyl)-bis-5,5'-thiazole-4,4'-dicarboxylate 
• 1370731-40-0 methyl 2-(p-methoxylphenyl)-5-phenylthiazole-4-carboxylate 

Relevant articles and documents

Cu(i)-Catalyzed oxidative homo-coupling of thiazoline-4-carboxylates: Synthesis of 4,4′-bithiazoline derivatives

Cu(i)-Catalyzed oxidative homo-coupling of thiazoline-4-carboxylates with good functional group tolerance has been developed. The methodology presented an efficient method to directly construct vicinal carbon-hetero quaternary centers existing in numerous functional molecules and could be applied to the synthesis of 4,4′-bithiazoles which are difficult to prepare by direct C-H activation.

Copper-catalyzed oxidation of azolines to azoles

We report herein convenient, aerobic conditions for the oxidation of thiazolines to thiazoles and data regarding the oxidation mechanism. These reactions feature operationally simple and environmentally benign conditions and proceed in good yield to afford the corresponding azoles, thus enabling the inexpensive preparation of valuable molecular building blocks. Incorporation of a novel diimine-ligated copper catalyst, [(MesDABMe) CuII(OH2)3]2+ [-OTf] 2, provides increased reaction efficiency in many cases. In other cases copper-free conditions involving a stoichiometric quantity of base affords superior results.

Titanium(IV)-mediated tandem deprotection-cyclodehydration of protected cysteine N-amides: Biomimetic syntheses of thiazoline- and thiazole-containing heterocycles

(matrix presented) The scope and limitations of TiCl4-mediated Δ2-thiazoline synthesis via tandem deprotection-dehydrocyclization of trityl-protected cysteine N-amides is presented. While chemical yields are acceptable (53-96%), the