256414-75-2 Usage
Description
5-[4-PHENYL-5-(TRIFLUOROMETHYL)-2-THIENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]-1,2,4-OXADIAZOLE is a complex organic compound characterized by its unique molecular structure, which includes phenyl, thiophene, and trifluoromethyl groups, as well as an oxadiazole ring. 5-[4-PHENYL-5-(TRIFLUOROMETHYL)-2-THIENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]-1,2,4-OXADIAZOLE has been found to possess significant biological activities and potential applications in the pharmaceutical industry.
Uses
Used in Pharmaceutical Industry:
5-[4-PHENYL-5-(TRIFLUOROMETHYL)-2-THIENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]-1,2,4-OXADIAZOLE is used as a medicament for treating and/or preventing cardiovascular conditions in patients with Fabry disease. It serves as a therapeutic agent to manage the symptoms and complications associated with this genetic disorder.
Used in Immunological Research:
In the field of immunology, SEW2871, a derivative of the compound, is used to mimic the effects of sphingosine-1 phosphate in HUVECs (human umbilical vein endothelial cells) to study the innate immunity rendered by long pentraxin 3. This application aids in understanding the complex interactions between the immune system and various signaling molecules.
Used in Transplant Medicine:
5-[4-PHENYL-5-(TRIFLUOROMETHYL)-2-THIENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]-1,2,4-OXADIAZOLE, through its selective agonist activity on the S1P1 receptor, is used to suppress the immune response in the context of transplant medicine. By decreasing the number of circulating lymphocytes in the blood, it helps prevent transplant rejection without causing bradycardia, which is a side effect associated with non-selective S1P receptor agonists.
Used in Autoimmune Disease Treatment:
The compound's ability to modulate the immune system also makes it a potential candidate for treating autoimmune diseases. By selectively targeting the S1P1 receptor, it can help reduce the immune system's overactivity, which is a common feature in various autoimmune conditions.
Biological Activity
Novel, potent and selective sphingosine-1-phosphate 1 (S1P 1 ) receptor agonist. Activates S1P 1 receptor with an EC 50 of 13 nM, but does not activate S1P 2 , S1P 3 , S1P 4 or S1P 5 receptors at concentrations up to 10 μ M. Cell-permeable and active in vivo .
Biochem/physiol Actions
SEW2871 is a selective agonist of spingosine-1 phosphate receptor. It exacerbates reperfusion arrhythmias by significantly prolonging the duration of ventricular tachycardia and ventricular fibrillation. SEW2871 modulates inflammatory reactions by influencing lymphocyte homing and cell migration. By the inhibition of proinflammatory molecules, SEW2871 reduces acute renal failure due to ischemia.
Check Digit Verification of cas no
The CAS Registry Mumber 256414-75-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,5,6,4,1 and 4 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 256414-75:
(8*2)+(7*5)+(6*6)+(5*4)+(4*1)+(3*4)+(2*7)+(1*5)=142
142 % 10 = 2
So 256414-75-2 is a valid CAS Registry Number.
InChI:InChI=1/C20H10F6N2OS/c21-19(22,23)13-8-4-7-12(9-13)17-27-18(29-28-17)15-10-14(11-5-2-1-3-6-11)16(30-15)20(24,25)26/h1-10H
