256418-85-6

Basic information

• Product Name: 2-Azetidinecarboxylic acid, 1-[(1,1-dimethylethyl)dimethylsilyl]-4-oxo-3-(phenylmethyl)-, (2R,3S)-
• CAS NO: 256418-85-6
• Molecular Formula: C17H25NO3Si
• Molecular Weight: 319.476
• Mol File: 256418-85-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-Azetidinecarboxylic acid, 1-[(1,1-dimethylethyl)dimethylsilyl]-4-oxo-3-(phenylmethyl)-, (2R,3S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Azetidinecarboxylic acid, 1-[(1,1-dimethylethyl)dimethylsilyl]-4-oxo-3-(phenylmethyl)-, (2R,3S)-(256418-85-6)
• EPA Substance Registry System: 2-Azetidinecarboxylic acid, 1-[(1,1-dimethylethyl)dimethylsilyl]-4-oxo-3-(phenylmethyl)-, (2R,3S)-(256418-85-6)

Safety Data

• Hazardous Substances Data: 256418-85-6(Hazardous Substances Data)

Upstream product

• 82938-50-9 (4R)-1-(tert-butyldimethylsilyl)-2-oxoazetidine-4-carboxylic acid 
• 100-39-0 benzyl bromide 

Downstream Products

• 402563-61-5 (3S,4S)-3-benzyl-4-[4-(1,1-diphenylmethoxycarbonyl)phenoxy]-1-[(S)-1-(phenylethyl)aminocarbonyl]azetidin-2-one 
• 256409-76-4 (3S,4S)-3-benzyl-4-[4-(1,1-diphenylmethoxycarbonyl)phenoxy]-1-[(R)-1-(phenylethyl)aminocarbonyl]azetidin-2-one 
• 402563-62-6 (3S,4R)-3-benzyl-4-[4-(1,1-diphenylmethoxycarbonyl)phenoxy]-1-[(S)-1-(phenylethyl)aminocarbonyl]azetidin-2-one 
• 256409-94-6 (3S,4R)-3-benzyl-4-[4-(1,1-diphenylmethoxycarbonyl)phenoxy]-1-[(R)-1-(phenylethyl)aminocarbonyl]azetidin-2-one 
• 402563-64-8 (2S,3S)-3-Benzyl-2-[4-(4-methyl-piperazine-1-carbonyl)-phenoxy]-4-oxo-azetidine-1-carboxylic acid ((S)-1-phenyl-ethyl)-amide 
• 256409-67-3 (2S,3S)-3-Benzyl-2-[4-(4-methyl-piperazine-1-carbonyl)-phenoxy]-4-oxo-azetidine-1-carboxylic acid ((R)-1-phenyl-ethyl)-amide 
• 256410-09-0 (2R,3S)-3-Benzyl-2-[4-(4-methyl-piperazine-1-carbonyl)-phenoxy]-4-oxo-azetidine-1-carboxylic acid ((S)-1-phenyl-ethyl)-amide 
• 256409-90-2 (2R,3S)-3-Benzyl-2-[4-(4-methyl-piperazine-1-carbonyl)-phenoxy]-4-oxo-azetidine-1-carboxylic acid ((R)-1-phenyl-ethyl)-amide 
• 402563-63-7 (3S,4S)-3-benzyl-4-(4-carboxy)phenoxy-1-[(S)-1-(phenylethyl)aminocarbonyl]azetidin-2-one 
• 256409-65-1 4-[(2S,3S)-3-Benzyl-4-oxo-1-((R)-1-phenyl-ethylcarbamoyl)-azetidin-2-yloxy]-benzoic acid 
• 256410-08-9 (3S,4R)-3-benzyl-4-(4-carboxy)phenoxy-1-[(S)-1-(phenylethyl)aminocarbonyl]azetidin-2-one 
• 256409-89-9 (3S,4R)-3-benzyl-4-(4-carboxy)phenoxy-1-[(R)-1-(phenylethyl)aminocarbonyl]azetidin-2-one 
• 256418-89-0 (3S,4R)-3-benzyl-4-[4-(1,1-diphenylmethoxycarbonyl)phenoxy]azetidin-2-one 
• 256418-88-9 (3S,4S)-3-benzyl-4-[4-(1,1-diphenylmethoxycarbonyl)phenoxy]azetidin-2-one 

Relevant articles and documents

Design, synthesis and pharmacological evaluation of 3-benzylazetidine-2-one-based human chymase inhibitors

3-Benzylazetidine-2-one derivatives were designed and evaluated as a novel series of chymase inhibitors. Structure-activity relationship studies of 3-benzylazetidine-2-ones led to compounds 23, which exhibited 3.1nM inhibition of human chymase and enhancement of stability in human plasma (t1/2 6 h). Copyright