256442-88-3Relevant articles and documents
Phthalazine PDE4 inhibitors. Part 2: The synthesis and biological evaluation of 6-methoxy-1,4-disubstituted derivatives
Napoletano, Mauro,Norcini, Gabriele,Pellacini, Franco,Marchini, Francesco,Morazzoni, Gabriele,Ferlenga, Pierpaolo,Pradella, Lorenzo
, p. 33 - 37 (2007/10/03)
This communication describes the synthesis and in vitro evaluation of a novel and potent series of phosphodiesterase type IV (PDE4) inhibitors. The compounds described present substituents in position 4 of the phthalazine ring to replace the commonly obse