256461-75-3Relevant articles and documents
Structure-based design and synthesis of non-nucleoside, potent, and orally bioavailable adenosine deaminase inhibitors
Terasaka, Tadashi,Okumura, Hiroyuki,Tsuji, Kiyoshi,Kato, Takeshi,Nakanishi, Isao,Kinoshita, Takayoshi,Kato, Yasuko,Kuno, Masako,Seki, Nobuo,Naoe, Yoshinori,Inoue, Takeshi,Tanaka, Kohichiro,Nakamura, Katsuya
, p. 2728 - 2731 (2007/10/03)
We disclose optimization efforts based on the novel non-nucleoside adenosine deaminase (ADA) inhibitor, 4 (Ki = 680 nM). Structure-based drug design utilizing the crystal structure of the 4/ADA complex led to discovery of 5 (Ki = 11