256474-26-7Relevant articles and documents
Chemo-enzymatic synthesis of (R)- and (S)-3,4-dichlorophenylbutanolide intermediate in the synthesis of sertraline
Barbieri, Cinzia,Caruso, Enrico,D'Arrigo, Paola,Pedrocchi Fantoni, Giuseppe,Servi, Stefano
, p. 3931 - 3937 (1999)
3,4-Dichlorophenacylchloride was reduced with whole cell biocatalysts to give the (R)- or (S)-chlorohydrine in high yields and good to high enantiomeric excess. Yields and enantiomeric purity of the (S)-enantiomer were increased to 95 and >98%, respective
One-pot route to β-adrenergic blockers via enantioselective organocatalysed epoxidation of terminal alkenes as a key step
Held, Felix E.,Wei, Shengwei,Eder, Kathrin,Tsogoeva, Svetlana B.
, p. 32796 - 32801 (2014/08/18)
A convenient and environmentally attractive one-pot two-step process for the synthesis of β-adrenergic blockers via Shi's organocatalytic epoxidation of terminal alkenes and subsequent aminolysis reaction of epoxides with isopropylamine under mild reaction conditions has been developed. This journal is the Partner Organisations 2014.
Effective asymmetric epoxidation of styrenes by chiral dioxirane
Goeddel, David,Shu, Lianhe,Yuan, Yi,Wong, O. Andrea,Wang, Bin,Shi, Yian
, p. 1715 - 1717 (2007/10/03)
High enantioselectivity (80-92% enantiomeric excess (ee)) has been obtained for the epoxidation of various styrenes using an easily prepared ketone (4) catalyst.
