256487-77-1

Basic information

• Product Name: N-Boc-4-oxo-L-proline methyl ester
• Synonyms: 1-tert-butyl 2-Methyl (2R)-4-oxopyrrolidine-1,2-dicarboxylate;Methyl N-Boc-4-keto-D-prolinate;(R)-N-Boc-2-Methoxycarbonyl-4-pyrrolidone;(2R)-4-oxo-1,2-Pyrrolidinedicarboxylic acid 1-(tert-butyl) 2-methyl ester;Boc-4-oxo-D-proline Methyl ester;Methyl (2R)-1-Boc-4-oxo-pyrrolidinecarboxylate;(2R)-4-oxo-1,2-Pyrrolidinedicarboxylic acid 1-(1,1-dimethylethyl) 2-methyl ester;1-O-tert-butyl 2-O-methyl (2R)-4-oxopyrrolidine-1,2-dicarboxylate
• CAS NO: 256487-77-1
• Molecular Formula: C₁₁H₁₇NO₅
• Molecular Weight: 243.25638
• Mol File: 256487-77-1.mol
• Article Data: 16

Chemical Properties

• Melting Point: 42-46℃
• Boiling Point: 333.149 °C at 760 mmHg
• Flash Point: 155.283 °C
• Appearance: /
• Density: 1.209
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.488
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -3.86±0.40(Predicted)
• CAS DataBase Reference: N-Boc-4-oxo-L-proline methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: N-Boc-4-oxo-L-proline methyl ester(256487-77-1)
• EPA Substance Registry System: N-Boc-4-oxo-L-proline methyl ester(256487-77-1)

Safety Data

• Hazard Codes: Xn:Harmful
• Statements: R20/21/22:; R41:
• Safety Statements: S26:; S36/37:; S39:
• HazardClass: IRRITANT
• Hazardous Substances Data: 256487-77-1(Hazardous Substances Data)

Usage

Uses

N-Boc-4-oxo-D-Proline methyl ester is a useful chemical reagent.

InChI:InChI=1/C11H17NO5/c1-11(2,3)17-10(15)12-6-7(13)5-8(12)9(14)16-4/h8H,5-6H2,1-4H3/t8-/m0/s1

Upstream product

• 114676-69-6 (2R,4R)-1-tert-butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 114676-59-4 (2R,4R)-4-hydroxy-2-methoxycarbonylpyrrolidine hydrochloride 
• 2584-71-6 cis-hydroxy-D-proline 
• 135042-17-0 (2R,4S)-1-tert-butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate 
• 178962-09-9 methyl (2R,4S)-4-hydroxypyrrolidine-2-carboxylate 
• 3398-22-9 trans-4-hydroxyproline 
• 135042-12-5 (4R)-1-(tert-butoxycarbonyl)-4-hydroxy-D-proline 
• 77449-94-6 (2R,4R)-4-hydroxypyrrolidine-2-carboxylic acid hydrochloride 

Downstream Products

• 647857-74-7 methyl (R)-1-tert-butoxycarbonyl-4,4-difluoropyrrolidine-2-carboxylate 
• 647857-60-1 (2R,4R)-1-tert-butyl 2-methyl 4-hydroxy-4-(trifluoromethyl)pyrrolidine-1,2-dicarboxylate 
• 114676-69-6 (2R,4R)-1-tert-butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate 
• 1314028-41-5 C₁₂H₁₄FNO₂ 
• 1217779-98-0 C₁₂H₁₄FNO₂*ClH 
• 536747-87-2 (R)-N-(tert-butoxycarbonyl)-4,4-difluoropyrrolidine-2-carboxylic acid 
• 475561-89-8 4-fluoro-1H-pyrrole-2-carboxylic acid methyl ester 
• 915230-14-7 (S)-methyl-4,4-difluoropyrrolidine-2-carboxylate trifluoroacetate 
• 470482-36-1 (2R)-1-tert-butyl 2-methyl 4-hydroxy-4-(trifluoromethyl)pyrrolidine-1,2-dicarboxylate 

Relevant articles and documents

Pyrimidine derivative and application thereof in medicines

The invention discloses a pyrimidine derivative and application thereof in medicines, and particularly relates to a novel pyrimidine derivative and a pharmaceutical composition containing the compound. The invention also relates to a method for preparing the compound and the pharmaceutical composition, and application of the compound and the pharmaceutical composition in preparation of drugs for treating KRAS G12C-mediated diseases and/or symptoms, especially in preparation of drugs for treating cancers.

Amino 6-membered ring derivative and pharmaceutical applications thereof including the use for manufacturing dipeptidyl peptidase-4(IDPP-IV) inhibitor

The present invention relates to an amino 6-membered ring derivative and pharmaceutical applications thereof, which specifically relates to the amino 6-membered ring derivative represented by the general formula (I) or stereoisomers thereof, pharmaceutically acceptable salts thereof, a prodrug, a pharmaceutical composition comprising the derivative, and the pharmaceutical use for manufacturing dipeptidyl peptidase-4(IDPP-IV) inhibitor, wherein the definition of each substituent in the general formula (I) is the same as described in the specification.

PHENOXYETHYL CYCLIC AMINE DERIVATIVES AND THEIR ACTIVITY AS EP4 RECEPTOR MODULATORS

The present invention provides a compound of the Formula (I): wherein X, R, R1,R2,R3, R4,R5,R6, R7, R8, and R9 are as defined herein, or a pharmaceutically acceptable salt thereof.