256663-37-3

Basic information

• Product Name: 2-methyl-3-phenyl-pent-4-enoic acid
• Synonyms: 2-methyl-3-phenyl-pent-4-enoic acid
• CAS NO: 256663-37-3
• Molecular Weight: 190.242
• Mol File: 256663-37-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-methyl-3-phenyl-pent-4-enoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methyl-3-phenyl-pent-4-enoic acid(256663-37-3)
• EPA Substance Registry System: 2-methyl-3-phenyl-pent-4-enoic acid(256663-37-3)

Safety Data

• Hazardous Substances Data: 256663-37-3(Hazardous Substances Data)

Upstream product

• 104-54-1 3-Phenylpropenol 
• 115-80-0 Triethyl orthopropionate 
• 78761-38-3 cinnamyl propionate 
• 40630-85-1 cinnamyl 2-bromopropanoate 
• 21040-45-9 Cinnamyl acetate 
• 31469-22-4 1,1-bis(trimethylsilyloxy)prop-1-ene 
• 300-57-2 allylbenzene 

Downstream Products

• 93845-08-0 methyl 2-methyl-3-phenylpent-4-enoate 

Relevant articles and documents

Palladium-Catalyzed Regiocontrollable Reductive Heck Reaction of Unactivated Aliphatic Alkenes

A general Pd-catalyzed intermolecular reductive Heck reaction of both terminal and internal unactivated aliphatic alkenes has been first developed. This method affords γ- and δ-arylated alkyl carboxylic acid derivatives in high yields with complete anti-Markovnikov selectivity. Notably, the coupling process is stereoretentive for the alkyl chain. Mechanistically, alkyl palladacycle intermediates stabilized by directing group and ligand, hydride species multigenerated from PS/TFA reductant, are two key factors that successfully promote the reaction and regioselectivity.

Indium-mediated Reformatsky-Claisen rearrangement

A new variant of the Reformatsky-Claisen rearrangement is described. The reaction of substituted allyl α-bromoacetates with indium and indium(III) chloride under ultrasonication provides a general entry into the functionalized synthon.

Transition-metal catalyzed synthesis of δ-hydroxy-γ-lactones from bis(trimethylsilyl) ketene acetals and allylic acetates via γ-unsaturated carboxylic acids. Comments on the formation of α-cyclopropyl carboxylic acids

Bis(trimethylsilyl)ketene acetals react with allylic acetates in the presence of Pd(0) complexes to give γ-unsaturated carboxylic acids together with α-cyclopropyl carboxylic acids. The unsaturated acids can be converted catalytically to δ-hydroxy-yγ-lactones by the H2O2/MTO system (methyltrioxorhenium) and to butenolides by Pd(II) catalyzed intramolecular cyclization reactions. The structure of two of these lactones has been established by X-ray analysis. The mechanism of the formation of the cyclopropanic acids will be discussed.