25693-41-8

Basic information

• Product Name: ETHYL 4-HYDROXY-2-MORPHOLINOPYRIMIDINE-5-CARBOXYLATE
• Synonyms: ETHYL 4-HYDROXY-2-MORPHOLINOPYRIMIDINE-5-CARBOXYLATE
• CAS NO: 25693-41-8
• Molecular Formula: C₁₁H₁₅N₃O₄
• Molecular Weight: 253.25
• Mol File: 25693-41-8.mol
• Article Data: 6

Chemical Properties

• Melting Point: 168-170 °C(Solv: ethanol (64-17-5))
• Appearance: /
• Density: 1.40±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 9.10±0.50(Predicted)
• CAS DataBase Reference: ETHYL 4-HYDROXY-2-MORPHOLINOPYRIMIDINE-5-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 4-HYDROXY-2-MORPHOLINOPYRIMIDINE-5-CARBOXYLATE(25693-41-8)
• EPA Substance Registry System: ETHYL 4-HYDROXY-2-MORPHOLINOPYRIMIDINE-5-CARBOXYLATE(25693-41-8)

Safety Data

• Hazardous Substances Data: 25693-41-8(Hazardous Substances Data)

Usage

General Description

ETHYL 4-HYDROXY-2-MORPHOLINOPYRIMIDINE-5-CARBOXYLATE is a chemical compound with the molecular formula C11H14N4O4. It is a pyrimidine derivative that contains a morpholine ring and a carboxylate group. This chemical is commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals. It has shown potential biological activities, including antifungal and antibacterial properties. Additionally, it has been studied for its potential use in the treatment of certain neurological disorders. Overall, ETHYL 4-HYDROXY-2-MORPHOLINOPYRIMIDINE-5-CARBOXYLATE is a versatile compound with various potential applications in the field of medicinal chemistry.

Upstream product

• 5638-78-8 morpholinoformamidine hydrochloride 
• 87-13-8 diethyl 2-ethoxymethylenemalonate 
• 157415-17-3 Morpholine-4-carboxamidine; hydrobromide 
• 851758-36-6 2-morpholin-4-yl-4-(4-nitro-benzyloxy)-pyrimidine-5-carboxylic acid ethyl ester 
• 157415-17-3 morpholine-4-carboxamidine hydrobromide 
• 17238-66-3 morpholine-4-carboxamidine 
• 110-91-8 morpholine 
• 53554-29-3 ethyl 3,4-dihydro-2-methylthio-4-oxopyrimidine-5-carboxylate 

Downstream Products

• 34750-23-7 ethyl 4-chloro-2-(morpholin-1-yl)pyrimidine-5-carboxylate 
• 1353875-60-1 ethyl 4-((4-methoxybenzyl)amino)-2-(4-morpholinyl)-5-pyrimidine-carboxylate 

Relevant articles and documents

Microwave-assisted synthesis and antibacterial evaluation of new derivatives of 1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one

Synthesis of new 1,2-dihydro-3H-pyrazolo[3,4-d] pyrimidin-3-ones 4-6 starting with ethyl 4-hydroxy-2-methylthio-pyrimidine-5-carboxylate (1) under classical heating and microwave-induced conditions is reported. The antibacterial activities of the synthesized compounds were evaluated using chloramphenicol and streptomycin as reference drugs.

Optimisation of pharmacokinetic properties in a neutral series of 11β-HSD1 inhibitors

11β-HSD1 is increasingly seen as an attractive target for the treatment of type II diabetes and other elements of the metabolic syndrome. In this program of work we describe how a series of neutral 2-thioalkyl-pyridine 11β-HSD1 inhibitors were optimized in terms of their pharmacokinetic properties to give compounds with excellent bioavailability in both rat and dog through a core change to pyrimidine. A potential reactive metabolite issue with 4-thioalkyl-pyrimidines was circumvented by a switch from sulfur to carbon substitution.

PYRIMIDINES AS INHIBITORS OF PHOSPHOINOSITIDE -3-KINASES (PI3K)

The present invention provides pyrimidines of Formula (I): wherein R4, R6, and Y have any of the values defined therefor in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment