256951-82-3

Basic information

• Product Name: Benzeneacetonitrile, 2-cyano-4-fluoro- (9CI)
• Synonyms: Benzeneacetonitrile, 2-cyano-4-fluoro- (9CI);2-Cyano-4-fluorobenzeneacetonitrile
• CAS NO: 256951-82-3
• Molecular Formula: C₉H₅FN₂
• Molecular Weight: 160.1478032
• Product Categories: HALIDE
• Mol File: 256951-82-3.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzeneacetonitrile, 2-cyano-4-fluoro- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneacetonitrile, 2-cyano-4-fluoro- (9CI)(256951-82-3)
• EPA Substance Registry System: Benzeneacetonitrile, 2-cyano-4-fluoro- (9CI)(256951-82-3)

Safety Data

• Hazardous Substances Data: 256951-82-3(Hazardous Substances Data)

Usage

General Description

Benzeneacetonitrile, 2-cyano-4-fluoro- (9CI) is a chemical compound with the molecular formula C9H6FN. It is a colorless liquid that is commonly used in the manufacturing of pharmaceuticals, pesticides, and other organic compounds. The compound is known for its strong odor and is classified as a hazardous material with potential health risks if not handled properly. It is also considered a potential environmental pollutant, and its usage is regulated in many countries. The chemical's properties and structure make it valuable in various industrial processes, despite the associated risks.

Upstream product

• 64248-64-2 2,5-difluorobenzonitrile 
• 1116-98-9 cyanoacetic acid tert-butyl ester 
• 105-56-6 ethyl 2-cyanoacetate 
• 105-34-0 methyl 2-cyanoacetate 

Downstream Products

• 256951-83-4 4-cyano-4-(2-cyano-4-fluorophenyl)piperidine-1-carboxylic acid tert-butyl ester 
• 265985-79-3 4-cyano-4-(2-cyano-4-fluorophenyl)piperidine 
• 256951-84-5 1-(3-N-bocaminopropyl)-4-cyano-4-(2-cyano-4-fluorophenyl)-piperidine 
• 1425605-95-3 7-fluoro-3-phenylisoquinolin-1-amine 

Relevant articles and documents

Nickel-Catalyzed Tandem Reaction of Functionalized Arylacetonitriles with Arylboronic Acids in 2-MeTHF: Eco-Friendly Synthesis of Aminoisoquinolines and Isoquinolones

The first example of the nickel-catalyzed tandem addition/cyclization of 2-(cyanomethyl)benzonitriles with arylboronic acids in 2-MeTHF has been developed, which provides the facile synthesis of aminoisoquinolines with good functional group tolerance under mild conditions. This chemistry has also been successfully applied to the synthesis of isoquinolones by the tandem reaction of methyl 2-(cyanomethyl)benzoates with arylboronic acids. The use of the bio-based and green solvent 2-MeTHF as the reaction medium makes the synthesis process environmentally benign. The synthetic utility of this chemistry is also indicated by the synthesis of biologically active molecules.

ANTIBACTERIAL COMPOUNDS HAVING BROAD SPECTRUM OF ACTIVITY

The present invention relates to novel antibacterial compounds, pharmaceutical compositions containing them and their use as antimicrobials.

Dihydropyridinones and pyrrolinones useful as alpha 1A adrenoceptor antagonists

Novel dihydropyridinone and pyrrolinone compounds and pharmaceutically acceptable salts thereof are disclosed. The synthesis of these compounds and their use as alpha1aadrenergic receptor antagonists is also described. One application of these compounds is in the treatment of benign prostatic hyperplasia. These compounds are selective in their ability to relax smooth muscle tissue enriched in the alpha1areceptor subtype without at the same time inducing hypotension. One such tissue is found surrounding the urethral lining. Therefore, one utility of the instant compounds is to provide acute relief to males suffering from benign prostatic hyperplasia, by permitting less hindered urine flow. Another utility of the instant compounds is provided by combination with a human 5-alpha reductase inhibitory compound, such that both acute and chronic relief from the effects of benign prostatic hyperplasia can be achieved.