25755-82-2

Basic information

• Product Name: 3-(4-METHYLPHENYL)-5(4H)-ISOXAZOLONE
• Synonyms: 3-(4-METHYLPHENYL)-5(4H)-ISOXAZOLONE;3-p-tolylisoxazol-5-one
• CAS NO: 25755-82-2
• Molecular Formula: C₁₀H₉NO₂
• Molecular Weight: 175.18396
• Mol File: 25755-82-2.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-(4-METHYLPHENYL)-5(4H)-ISOXAZOLONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-METHYLPHENYL)-5(4H)-ISOXAZOLONE(25755-82-2)
• EPA Substance Registry System: 3-(4-METHYLPHENYL)-5(4H)-ISOXAZOLONE(25755-82-2)

Safety Data

• Hazardous Substances Data: 25755-82-2(Hazardous Substances Data)

Upstream product

• 5868-55-3 (3-p-tolyl-isoxazol-5-yl)-boronic acid 
• 27835-00-3 ethyl (4-methylbenzoyl)acetate 
• 124-38-9 carbon dioxide 
• 2089-33-0 4-methylacethophenone oxime 
• 441285-82-1 (Z)-3-amino-3-p-tolylacrylic acid ethyl ester 
• 13820-14-9 4-methylbenzonitrile oxide 
• 1227841-23-7 (E)-4-methylbenzaldehyde O-3-(4-methylphenyl)propioloyl oxime 
• 1076-59-1 3-phenyl-4H-isoxazol-5-one 
• 122-00-9 para-methylacetophenone 
• 105-36-2 ethyl bromoacetate 
• 104-85-8 para-methylbenzonitrile 
• 616-38-6 carbonic acid dimethyl ester 
• 22027-51-6 3-oxo-3-p-tolyl-propionic acid methyl ester 

Downstream Products

• 25755-83-3 5-methoxy-3-(4-methylphenyl)isoxazole 
• 65927-00-6 5-chloro-4-dichloromethyl-3-p-tolyl-isoxazole 
• 65927-03-9 3,3'-di-p-tolyl-2H-[4,5']biisoxazolyl-5-one 
• 7118-66-3 5-methyl-2-(4-methylphenyl)-1H-benzimidazole 
• 139436-60-5 6-methyl-2-p-tolylquinoxaline 
• 1792-41-2 2,5-dimethylbenzimidazole 
• 142335-30-6 7-Methyl-4-p-tolyl-1,3-dihydro-benzo[b][1,4]diazepin-2-one 
• 7118-65-2 5-chloro-2-(p-tolyl)-1H-benzo[d]imidazole 
• 139436-64-9 6-chloro-2-(p-tolyl)quinoxaline 
• 2818-69-1 5-chloro-2-methyl-1H-benzimidazole 
• 142335-33-9 7-Chloro-4-p-tolyl-1,3-dihydro-benzo[b][1,4]diazepin-2-one 
• 615-15-6 2-Methyl-1H-benzimidazole 
• 120893-29-0 4-p-Tolyl-1,3-dihydro-benzo[b][1,4]diazepin-2-one 
• 120-03-6 2-(p-tolyl)-1H-benzimidazole 

Relevant articles and documents

Palladium Catalyzed Ring Expansion Reaction of Isoxazolones with Isocyanides: Synthesis of 1,3-Oxazin-6-One Derivatives

A palladium catalyzed ring expansion reaction of isoxazolones with isocyanides was disclosed. In the reaction, a cascade process involving ring-opening/cyclization was suggested. The reaction features high atomic economy due to no elimination of CO2 occurred. Moreover, products obtained demonstrate aggregation-induced emission properties with relatively high solid-state emission efficiencies. (Figure presented.).

Palladium catalyzed insertion reaction of isocyanides with 3-arylisoxazol-5(4 H)-ones: Synthesis of 4-aminomethylidene isoxazolone derivates

A palladium catalyzed insert reaction of isocyanides to 3-arylisoxazol-5(4H)-ones for the construction of 4-aminomethylidene isoxazolone derivates is reported. In this transformation, only the C-H bond of the methylene group was involved while the remaining ring structure was retained. In general, this work provided a new protocol for the synthesis of 4-aminomethylidene isoxazolones.

Reformatsky and Blaise reactions in flow as a tool for drug discovery. One pot diversity oriented synthesis of valuable intermediates and heterocycles

The application of Reformatsky and Blaise reactions for the preparation of a diverse set of valuable intermediates and heterocycles in a one-pot protocol is described. To achieve this goal, a greener activation protocol for zinc in flow conditions has been developed to introduce this metal efficiently into α-bromoacetates. The organozinc compounds were added to a diverse set of ketones and nitriles to obtain a wide range of functional groups and heterocyclic systems.