257622-59-6

Basic information

• Product Name: Benzoic acid, 3-[(bromoacetyl)amino]-, methyl ester
• CAS NO: 257622-59-6
• Molecular Formula: C10H10BrNO3
• Molecular Weight: 272.098
• Mol File: 257622-59-6.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 3-[(bromoacetyl)amino]-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 3-[(bromoacetyl)amino]-, methyl ester(257622-59-6)
• EPA Substance Registry System: Benzoic acid, 3-[(bromoacetyl)amino]-, methyl ester(257622-59-6)

Safety Data

• Hazardous Substances Data: 257622-59-6(Hazardous Substances Data)

Upstream product

• 4518-10-9 Methyl 3-aminobenzoate 
• 598-21-0 2-Bromoacetyl bromide 

Downstream Products

• 651749-39-2 3-[2-(3-isopropylphenylamino)acetylamino]benzoic acid methyl ester 
• 651749-40-5 3-[2-(3-isopropylphenylamino)ethylamino]benzoic acid methyl ester 
• 651748-77-5 3-[3-(3-isopropyl-phenyl)-2-oxo-imidazolidin-1-yl]-benzoic acid 
• 430470-37-4 methyl 3-[2-(4-isopropyl-3-methyl-phenoxy)-acetylamino]-benzoate 

Relevant articles and documents

Novel selective ido1 inhibitors with isoxazolo[5,4-d]pyrimidin-4(5h)-one scaffold

Indoleamine 2,3-dioxygenase 1 (IDO1) is a promising target in immunomodulation of several pathological conditions, especially cancers. Here we present the synthesis of a series of IDO1 inhibitors with the novel isoxazolo[5,4-d]pyrimidin-4(5H)-one scaffold. A focused library was prepared using a 6-or 7-step synthetic procedure to allow a systematic investigation of the structure-activity relationships of the described scaffold. Chemistry-driven modifications lead us to the discovery of our best-in-class inhibitors possessing p-trifluoromethyl (23), p-cyclohexyl (32), or p-methoxycarbonyl (20, 39) substituted aniline moieties with IC50 values in the low micromolar range. In addition to hIDO1, compounds were tested for their inhibition of indoleamine 2,3-dioxygenase 2 and tryptophan dioxygenase, and found to be selective for hIDO1. Our results thus demon-strate a successful study on IDO1-selective isoxazolo[5,4-d]pyrimidin-4(5H)-one inhibitors, defining promising chemical probes with a novel scaffold for further development of potent small-molecule immunomodulators.

Ureido substituted benzoic acid compounds and their use for nonsense suppression and the treatment of disease

The invention encompasses ureido substituted benzoic acid compounds, compositions comprising the compounds and methods for treating or preventing diseases associated with nonsense mutations of mRNA by administering these compounds or compositions.

UREIDO SUBSTITUTED BENZOIC ACID COMPOUNDS AND THEIR USE FOR NONSENSE SUPPRESSION AND THE TREATMENT OF DISEASE

The invention encompasses ureido substituted benzoic acid compounds, compositions comprising the compounds and methods for treating or preventing diseases associated with nonsense mutations of mRNA by administering these compounds or compositions.