257639-98-8 Usage
Description
CP 154526, also known as CP-154526 Hydrochloride, is a selective, non-peptide antagonist of corticotropin-releasing factor receptors (CRF1). It is a pale yellow solid that effectively blocks CRF-induced adenylate cyclase activation and attenuates the activation of the hypothalamic-pituitary-adrenal (HPA) axis by CRF. Additionally, it exhibits anxiolytic-like activity in the rat elevated plus-maze test and has the ability to penetrate the brain.
Uses
Used in Pharmaceutical Industry:
CP 154526 is used as a therapeutic agent for the treatment of anxiety disorders and stress-related conditions. Its anxiolytic-like activity and ability to modulate the HPA axis make it a promising candidate for pharmaceutical applications.
Used in Research and Development:
CP 154526 is used as a research tool for studying the role of CRF1 receptors in various physiological and pathological processes. Its selective antagonism of CRF1 receptors allows researchers to investigate the underlying mechanisms of stress, anxiety, and other related conditions.
Used in Drug Delivery Systems:
CP 154526 can be incorporated into drug delivery systems to improve its bioavailability and therapeutic outcomes. By utilizing various organic and metallic nanoparticles as carriers, the delivery, efficacy, and overall performance of CP 154526 in treating anxiety and stress-related disorders can be enhanced.
Biochem/physiol Actions
CP-154526 is a selective, non-peptide antagonist of corticotropin releasing factor receptors (CRF1).
Check Digit Verification of cas no
The CAS Registry Mumber 257639-98-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,5,7,6,3 and 9 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 257639-98:
(8*2)+(7*5)+(6*7)+(5*6)+(4*3)+(3*9)+(2*9)+(1*8)=188
188 % 10 = 8
So 257639-98-8 is a valid CAS Registry Number.
