25785-09-5

Basic information

• Product Name: 5-NITRO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID ETHYL ESTER
• Synonyms: ETHYL 5-NITRO-1-BENZOTHIOPHENE-2-CARBOXYLATE;5-NITRO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID ETHYL ESTER;Ethyl-5-Nitrobenzo[b]thiophene-2-carboxylate 97%
• CAS NO: 25785-09-5
• Molecular Formula: C₁₁H₉NO₄S
• Molecular Weight: 251.26
• Mol File: 25785-09-5.mol
• Article Data: 16

Chemical Properties

• Melting Point: 164-165°C
• Boiling Point: 402°C at 760 mmHg
• Flash Point: 196.9°C
• Appearance: /
• Density: 1.401g/cm³
• Vapor Pressure: 1.13E-06mmHg at 25°C
• Refractive Index: 1.65
• CAS DataBase Reference: 5-NITRO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 5-NITRO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID ETHYL ESTER(25785-09-5)
• EPA Substance Registry System: 5-NITRO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID ETHYL ESTER(25785-09-5)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 25785-09-5(Hazardous Substances Data)

Usage

General Description

5-NITRO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID ETHYL ESTER is a chemical compound with a molecular formula C12H9NO4S. It is an ethyl ester derivative of 5-nitrobenzothiophene-2-carboxylic acid and is commonly used in organic synthesis and pharmaceutical research. This chemical is known to possess various pharmacological properties, including antimicrobial and antifungal activities. It is also used as a building block in the synthesis of various pharmaceuticals and agrochemicals. However, it is important to handle this compound with proper care and in accordance with safety guidelines due to its potential toxicity and health hazards.

InChI:InChI=1/C11H9NO4S/c1-2-16-11(13)10-6-7-5-8(12(14)15)3-4-9(7)17-10/h3-6H,2H2,1H3

Upstream product

• 64-17-5 ethanol 
• 6345-55-7 5-nitrobenzo[b]thiophene-2-carboxylic acid 
• 98555-48-7 2-formyl-4-nitro-benzenesulfenyl bromide 
• 1007476-32-5 sodium ethyl acetylacetate enolate 
• 623-51-8 ethyl 2-sulfanylacetate 
• 6361-21-3 2-chloro-5-nitrobenzaldehyde 
• 105-36-2 ethyl bromoacetate 
• 23081-03-0 5,5'-dinitro-2,2'-disulfanediyl-bis-benzaldehyde 
• 82301-36-8 (2-formyl-4-nitro-phenylsulfanyl)-acetic acid 
• 55163-91-2 ethyl thioglycolate sodium salt 
• 27996-87-8 2-fluoro-5-nitrobenzaldehye 

Downstream Products

• 25785-10-8 ethyl 5-amino-1-benzothiophene-2-carboxylate 
• 6345-55-7 5-nitrobenzo[b]thiophene-2-carboxylic acid 
• 850074-18-9 5-formyl-benzo[b]thiophene-2-carboxylic acid ethyl ester 
• 530145-02-9 ethyl 5-(hydroxymethyl)-1-benzothiophene-2-carboxylate 
• 947513-36-2 C₁₈H₁₇NSO₂ 
• 947513-37-3 C₁₉H₁₉NSO₂ 
• 947513-39-5 C₂₀H₂₁NSO₂ 
• 4965-26-8 5-nitrobenzo[b]thiophene 
• 105191-14-8 5-Cyanbenzothiophen-2-carbonsaeure-ethylester 
• 154650-76-7 5-cyanobenzo[b]thiophene-2-carboxylic acid 
• 174774-80-2 t-butyl 4-[(5-cyanobenzo [b]thien-2-yl)carbonylamino]phenoxyacetate 
• 1026868-22-3 {4-[(5-methylsulfanylcarbonimidoyl-benzo[b]thiophene-2-carbonyl)-amino]-phenoxy}-acetic acid tert-butyl ester 
• 1026500-69-5 {4-[(5-mercaptocarbonimidoyl-benzo[b]thiophene-2-carbonyl)-amino]-phenoxy}-acetic acid tert-butyl ester 
• 29948-26-3 ethyl thieno[3,2-f]quinoline-2-carboxylate 

Relevant articles and documents

A straightforward expeditious synthesis of 5-nitrobenzo[b]thiophene-2- carbaldehyde

A high yielding one-pot synthesis of 5-nitrobenzo[b]thiophene-2- carbaldehyde is reported using the readily available,cheap starting material 2,5-dihydroxy-1,4-dithiane and 2-chloro-5-nitrobenzaldehyde.

Design, synthesis, and biological evaluation of novel benzo[b]thiophene-diaryl urea derivatives as potential anticancer agents

A hybrid pharmacophore approach was applied to design and synthesize a series of benzo[b]thiophene-diaryl urea derivatives 17a–g with potential anticancer effect. In vitro antiproliferative activities of all target compounds were evaluated against HT-29 a

Design, synthesis, and in vitro antiproliferative activity of novel Dasatinib derivatives

Two series of novel Dasatinib derivatives have been designed and synthesized, with their in vitro cytostatic effect screened on human chronic myeloid leukemia cell line K562 and human myeloid leukemia cell line U937. Some target compounds demonstrated sig