257955-59-2

Basic information

• Product Name: 3-(3,4-dimethoxy-phenyl)-10-methyl-10H-benzo[4,5]imidazo[2,1-c][1,2,4]triazin-4-one
• Synonyms: 3-(3,4-dimethoxy-phenyl)-10-methyl-10H-benzo[4,5]imidazo[2,1-c][1,2,4]triazin-4-one
• CAS NO: 257955-59-2
• Molecular Weight: 336.35
• Mol File: 257955-59-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-(3,4-dimethoxy-phenyl)-10-methyl-10H-benzo[4,5]imidazo[2,1-c][1,2,4]triazin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3,4-dimethoxy-phenyl)-10-methyl-10H-benzo[4,5]imidazo[2,1-c][1,2,4]triazin-4-one(257955-59-2)
• EPA Substance Registry System: 3-(3,4-dimethoxy-phenyl)-10-methyl-10H-benzo[4,5]imidazo[2,1-c][1,2,4]triazin-4-one(257955-59-2)

Safety Data

• Hazardous Substances Data: 257955-59-2(Hazardous Substances Data)

Upstream product

• 4732-70-1 3,4-dimethoxyphenylglyoxylic acid 

Relevant articles and documents

3-Aryl-[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-ones: Tricyclic heteroaromatic derivatives as a new class of benzodiazepine receptor ligands

A series of 3-substituted [1,2,4]triazino[4,3-c]benzimidazoles V were prepared and tested at the central benzodiazepine receptor (BzR). These compounds were designed as rigid analogues of the previously described N- benzylindolylglyoxylylamide derivatives IV. The title compounds V showed an affinity which depended directly on the presence of the N(10)-H group and an aromatic ring at position 3. Some of them elicited a 2- or 3-fold higher affinity with respect to that of the indolylglyoxylylamide derivatives IV (R=H). The GABA ratio and [35S]-tert-butylcyclophosphorothionate binding data revealed an efficacy profile of partial inverse agonists/antagonists for compounds 1c,e,f,j,k, and of a partial agonist for 2c. This last compound proved to be effective in antagonizing pentylenetetrazole-induced seizures in mice. Attempts were made to interpret the structure-affinity relationships of compounds V in the light of possible tautomeric equilibria involving the ligands.