25813-24-5

Basic information

• Product Name: 3,5-DibroMo-4-Methoxy-pyridine
• Synonyms: 3,5-Dibromo-4-methoxypyridine
• CAS NO: 25813-24-5
• Molecular Formula: C₆H₅Br₂NO
• Molecular Weight: 266.918
• Mol File: 25813-24-5.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 251.9±35.0 °C(Predicted)
• Appearance: /
• Density: 1.919±0.06 g/cm3(Predicted)
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 1.82±0.28(Predicted)
• CAS DataBase Reference: 3,5-DibroMo-4-Methoxy-pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-DibroMo-4-Methoxy-pyridine(25813-24-5)
• EPA Substance Registry System: 3,5-DibroMo-4-Methoxy-pyridine(25813-24-5)

Safety Data

• Hazardous Substances Data: 25813-24-5(Hazardous Substances Data)

Usage

General Description

3,5-Dibromo-4-methoxy-pyridine is a chemical compound with the molecular formula C6H5Br2NO, consisting of a pyridine ring with two bromine atoms at positions 3 and 5, and a methoxy group at position 4. It is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. This chemical is known for its pesticidal and fungicidal properties, and is often utilized in the development of new agricultural products. In addition, 3,5-dibromo-4-methoxy-pyridine can also act as a building block in the production of various specialty chemicals, making it a versatile and valuable compound in the chemical industry.

InChI:InChI=1S/C6H5Br2NO/c1-10-6-4(7)2-9-3-5(6)8/h2-3H,1H3

Upstream product

• 626-64-2 pyridin-4-ol 
• 25813-25-6 3,5-dibromo-4-hydroxypyridine 
• 67-56-1 methanol 
• 2457-48-9 3,4,5-tribromopyridine 
• 74-88-4 methyl iodide 
• 13626-17-0 3,5-dibromo-4-chloro-pyridine 
• 124-41-4 sodium methylate 

Downstream Products

• 1357093-77-6 N-(4-(5-bromo-4-methoxypyridin-3-yl)-3-methylphenyl)methanesulfonamide 
• 2683-35-4 3,5-dibromo-1-methylpyridin-4(1H)-one 
• 90110-13-7 3,5-dibromo-1-ethylpyridin-4(1H)-one 

Relevant articles and documents

BIARYL DERIVATIVE AND MEDICINE CONTAINING SAME

Provided is a compound showing excellent antifungal activity against Trichophyton fungus, which is a major causative microorganism of superficial mycosis, and high effectiveness on diseases caused by Trichophyton fungi. A biaryl derivative represented by the formula (I) or a salt thereof: wherein ring A is an optionally substituted phenyl, or an optionally substituted 5- or 6-membered ring heteroaryl (ring A may be further condensed to form an optionally substituted fused ring); Q is CH2, C=O, NH, O, S or the like; X1, X2 and X3 are CR1 or N; Y is CH or N; Z is CR2b or N; R2a and R2b are each a hydrogen atom, a halogen atom, an optionally substituted C1-C6 alkyl group, a C1-C6 haloalkyl group or the like; R2a and R2b may form, together with carbon atoms bonded thereto, an optionally substituted carbocycle, or an optionally substituted heterocycle.

Discovery of 2,4-dimethoxypyridines as novel autophagy inhibitors

Autophagy is a catabolic process, which mediates degradation of cellular components and has important roles in health and disease. Therefore, small molecule modulators of autophagy are in great demand. Herein, we describe a phenotypic high-content screen for autophagy inhibitors, which led to the discovery of a dimethoxypyridine-based class of autophagy inhibitors, which derive from previously reported, natural product-inspired MAP4K4 inhibitors. Comprehensive structure-activity relationship studies led to a potent compound, and biological validation experiments indicated that the mode of action was upstream or independent of mTOR.

COUMARIN DERIVATIVES AND METHODS OF USE IN TREATING HYPERPROLIFERATIVE DISEASES

Coumarin derivative compounds and methods for the treatment of hyperproliferative diseases, such as cancer, polycystic kidney disease, and fibrosis of different tissues (e.g., idiopathic pulmonary fibrosis), are provided. The methods include administering