258261-50-6

Basic information

• Product Name: (2,4-dimethyl-thiazol-5-yl)-(1-trityl-1H-imidazol-4-yl)-methanone
• Synonyms: (2,4-dimethyl-thiazol-5-yl)-(1-trityl-1H-imidazol-4-yl)-methanone
• CAS NO: 258261-50-6
• Molecular Weight: 449.576
• Mol File: 258261-50-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2,4-dimethyl-thiazol-5-yl)-(1-trityl-1H-imidazol-4-yl)-methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (2,4-dimethyl-thiazol-5-yl)-(1-trityl-1H-imidazol-4-yl)-methanone(258261-50-6)
• EPA Substance Registry System: (2,4-dimethyl-thiazol-5-yl)-(1-trityl-1H-imidazol-4-yl)-methanone(258261-50-6)

Safety Data

• Hazardous Substances Data: 258261-50-6(Hazardous Substances Data)

Upstream product

• 53137-27-2 2,4-dimethyl-thiazole-5-carboxylic acid 
• 96797-15-8 N-trityl-4⁽⁵⁾-iodoimidazole 
• 258261-48-2 N-methyl-N-methoxy-2,4-dimethylthiazole-5-carboxamide 

Relevant articles and documents

α2 Adrenoceptor agonists as potential analgesic agents. 1. (Imidazolylmethyl)oxazoles and -thiazoles

A series of (imidazolylmethyl)oxazoles and -thiazoles were prepared and evaluated as α2 adrenoceptor agonists. These compounds were also tested in in vivo paradigms that are predictive of analgesic activity. Variations in both the imidazole and thiazole portions of the molecule were investigated. Some of the more potent compounds such as 22, 26, 45, and 53 displayed α2 receptor binding in the 10-20 nM range and also had significant antinociceptive activity in the mouse abdominal irritant test (MAIT).