258278-64-7 Usage
Description
SE 175 is an organic nitrate compound, belonging to the same general class as nitroglycerin. It is designed to act as a NO-donor in vivo, where the nitrate group is reductively transformed into nitric oxide. The development of nitroxyacylated thiosalicylates, such as SE 175, aims to facilitate this reductive process and accelerate the release of NO. Notably, SE 175 demonstrates stability in buffer or saline solutions and has been shown to stimulate endothelial soluble guanylate cyclase and induce aortic vasorelaxation in rats with an EC50 of 20 μM, positioning it intermediate in potency between nitroglycerine and isosorbide dinitrate.
Uses
Used in Pharmaceutical Industry:
SE 175 is used as a NO-donor for the treatment of various cardiovascular conditions. Its application is based on its ability to stimulate endothelial soluble guanylate cyclase and induce aortic vasorelaxation, making it a potential therapeutic agent for conditions involving impaired blood flow or vascular health.
Used in Research and Development:
In the field of biomedical research, SE 175 serves as a valuable tool for studying the role of nitric oxide in biological processes and its potential applications in therapeutic interventions. Its intermediate potency between nitroglycerine and isosorbide dinitrate makes it an attractive candidate for comparative studies and the development of novel therapeutic strategies.
Used in Drug Delivery Systems:
SE 175 can be employed in the development of innovative drug delivery systems to enhance its bioavailability and therapeutic outcomes. By incorporating SE 175 into various carriers, such as organic and metallic nanoparticles, its delivery and efficacy can be improved, potentially leading to more effective treatments for cardiovascular conditions and other related health issues.
Check Digit Verification of cas no
The CAS Registry Mumber 258278-64-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,5,8,2,7 and 8 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 258278-64:
(8*2)+(7*5)+(6*8)+(5*2)+(4*7)+(3*8)+(2*6)+(1*4)=177
177 % 10 = 7
So 258278-64-7 is a valid CAS Registry Number.
InChI:InChI=1/C16H13NO6S/c1-22-15(18)13-4-2-3-5-14(13)24-16(19)12-8-6-11(7-9-12)10-23-17(20)21/h2-9H,10H2,1H3
258278-64-7Relevant articles and documents
No-donors, part 3: Nitrooxyacylated thiosalicylates and salicylates - Synthesis and biological activities
Endres, Stefan,Hacker, Andreas,Noack, Eike,Kojda, Georg,Lehmann, Jochen
, p. 895 - 901 (2007/10/03)
Organic nitrates release nitric oxide when incubated with thiosalicylic acid. S-Nitrooxyacylated esters and amides of thiosalicylic acid, together with the corresponding salicylates, were synthesized in order to perform a first in vitro evaluation of these new nitrate-thiol-hybrid prodrugs. These prodrugs might release NO in vivo after biotransformation without the use of endogenous reductives. None of these prodrugs released NO spontaneously when dissolved in buffer solution, but they did activate soluble guanylyl cyclase and induced vasodilatation of phenylephrine-pretreated male Wistar rat aorta in a potency range between that of isosorbiddinitrate and glycerole trinitrate.
