2585-23-1Relevant articles and documents
Design, synthesis, and biological evaluation of 2,4-diamino pyrimidine derivatives as potent FAK inhibitors with anti-cancer and anti-angiogenesis activities
Wang, Shan,Zhang, Rong-Hong,Zhang, Hong,Wang, Yu-Chan,Yang, Dan,Zhao, Yong-Long,Yan, Guo-Yi,Xu, Guo-Bo,Guan, Huan-Yu,Zhou, Yan-Hua,Cui, Dong-Bing,Liu, Ting,Li, Yong-Jun,Liao, Shang-Gao,Zhou, Meng
, (2021/06/09)
A series of 2,4-diamino pyrimidine (DAPY) derivatives were designed, synthesized, and evaluated as inhibitors of focal adhesion kinase (FAK) with antitumor and anti-angiogenesis activities. Most compounds effectively suppressed the enzymatic activities of
2-(4-methanoyl) anilino-4-aminopyrimidine derivatives and application thereof
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Paragraph 0031-0036, (2021/04/03)
The invention belongs to the technical field of chemical medicines, and particularly relates to 2-(4-methanoyl) anilino-4-aminopyrimidine derivatives and application thereof. According to the invention, nitryl, carboxyl, cyano and the like are adopted to
A Convenient One-Pot Synthesis of 1,5-Disubstituted Tetrazoles Containing an Amino or a Carboxy Group
Obushak, M. D.,Pokhodylo, N. T.,Shyyka, O. Ya.
, p. 802 - 812 (2020/07/03)
Abstract: A convenient method is proposed for constructing the tetrazole ring by a one-pot reaction of amides with phosphorus oxychloride and sodium azide. A series of 1,5-disubstituted tetrazoles containing an amino or a carboxy group, which present interest as buildings blocks for the synthesis of biologically active substances, were obtained.