258532-32-0Relevant articles and documents
Development of 3,4-dihydro-2H-benzo[1,4]oxazine derivatives as dual thromboxane A2 receptor antagonists and prostacyclin receptor agonists
Ohno, Michihiro,Tanaka, Yoichiro,Miyamoto, Mitsuko,Takeda, Takahiro,Hoshi, Kazuhiro,Yamada, Naohiro,Ohtake, Atsushi
, p. 2005 - 2021 (2007/10/03)
We discovered a novel series of 3,4-dihydro-2H-benzo[1,4]oxazin-8- yloxyacetic acid derivatives as potent dual-acting agents to block the TXA 2 receptor and to activate the PGI2 receptor. We report the synthesis, structure-activity r