25857-63-0Relevant articles and documents
Design, synthesis and biological activity of novel non-peptidyl endothelin converting enzyme inhibitors, 1-phenyl-tetrazole-formazan analogues
Yamazaki, Kazuto,Hasegawa, Hirohiko,Umekawa, Kayo,Ueki, Yasuyuki,Ohashi, Naohito,Kanaoka, Masaharu
, p. 1275 - 1278 (2002)
A novel non-peptidyl endothelin converting enzyme inhibitor was obtained through a pharmacophore analysis of known inhibitors and three-dimensional structure database search. Analogues of the new inhibitor were designed using the structure-activity relationship of known inhibitors and synthesized. In anesthetized rats, intraperitoneal administration of the analogues suppressed the pressor responses induced by big endothelin-1.