25860-59-7

Basic information

• Product Name: 2-Propenoic acid, 2-Methyl-3-(4-Methylphenyl)-
• Synonyms: 2-Propenoic acid, 2-Methyl-3-(4-Methylphenyl)-;2-METHYL-3-(4-METHYLPHENYL)PROP-2-ENOIC ACID(WXG01404)
• CAS NO: 25860-59-7
• Molecular Formula: C₁₁H₁₂O₂
• Molecular Weight: 176.21178
• Mol File: 25860-59-7.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Propenoic acid, 2-Methyl-3-(4-Methylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenoic acid, 2-Methyl-3-(4-Methylphenyl)-(25860-59-7)
• EPA Substance Registry System: 2-Propenoic acid, 2-Methyl-3-(4-Methylphenyl)-(25860-59-7)

Safety Data

• Hazardous Substances Data: 25860-59-7(Hazardous Substances Data)

Usage

General Description

2-Propenoic acid, 2-methyl-3-(4-methylphenyl)-, also known as p-Methylstyrylacrylic acid, is a chemical compound with the molecular formula C12H12O2. It is a derivative of acrylic acid and is commonly used in the production of polymers and resins. 2-Propenoic acid, 2-methyl-3-(4-methylphenyl)- is a white crystalline solid and is insoluble in water, but soluble in organic solvents. It is also used in the synthesis of pharmaceuticals and agrochemicals due to its ability to form stable complexes with metal ions. Additionally, it has potential applications in the field of photochemistry and photophysics due to its unique electronic and optical properties, making it a versatile and valuable chemical compound.

Upstream product

• 126356-05-6 methyl (E)-2-methyl-3-(4-methylphenyl)acrylate 
• 104-87-0 4-methyl-benzaldehyde 
• 123-62-6 propionic acid anhydride 
• 143165-01-9 methyl 2-(acetoxy(4-methylphenyl)methyl)acrylate 
• 115240-91-0 methyl 2-((hydroxy)(4-methylphenyl)methyl)prop-2-enoate 
• 1367876-24-1 [(Z)-2-methoxycarbonyl-3-(4-methylphenyl)-2-propenyl]triphenylphosphonium bromide 
• 139413-76-6 methyl (2Z)-2-(bromomethyl)-3-(4-methylphenyl)prop-2-enoate 
• 119346-67-7 ethyl (E)-2-methyl-3-(p-tolyl)acrylate 

Downstream Products

• 1012-15-3 α-methyl-β-(4-methylphenyl)propionic acid 
• 66309-83-9 2,6-dimethylindan-1-one 
• 1346513-35-6 C₂₃H₂₄O₂ 
• 56138-10-4 (2E)-2-methyl-3-(4-methylphenyl)-2-propen-1-ol 
• 336181-44-3 2-(1-methyl-2-p-tolyl-vinyl)-1H-benzoimidazole 
• 915137-62-1 1-((E)-3-Chloro-2-methyl-propenyl)-4-methyl-benzene 
• 1392325-28-8 ethyl (E)-6-(4-methylphenyl)-2-ethyl-5-methyl-3,4-dioxohex-5-enoate 

Relevant articles and documents

Discovery of a novel inhibitor of nitric oxide production with potential therapeutic effect on acute inflammation

Inflammation as a host's excessive immune response to stimulation, is involved in the development of numerous diseases. To discover novel anti-inflammatory agents and based on our previous synthetic work on marine natural product Chrysamide B, it and a series of derivatives were synthesized and evaluated for their anti-inflammatory activity on inhibition of LPS-induced NO production. Then the preliminary structure–activity relationships were conducted. Among them, Chrysamide B is the most potent anti-inflammatory agent with low cytotoxicity and strong inhibition on the production of NO (IC50 = 0.010 μM) and the activity of iNOS (IC50 = 0.082 μM) in LPS-stimulated RAW 264.7 cells. Primary studies suggested that the mechanism of action may be that it interfered the formation of active dimeric iNOS but not affected transcription and translation. Furthermore, its good performance of anti-inflammatory effect on LPS-induced multiple inflammatory cytokines production, carrageenan-induced paw edema, and endotoxin-induced septic mice, was observed. We believe that these findings would provide an idea for the further modification and research of these analogs in the future.

Pd-Catalyzed α-Selective C-H Functionalization of Olefins: En Route to 4-Imino-β-Lactams

Pd-catalyzed α-olefinic C-H activation of simple α,β-unsaturated olefins has been developed. 4-imino-β-lactam derivatives were readily synthesized via activation of α-olefinic C-H bonds with excellent cis stereoselectivity. A wide range of heterocycles at the β-position are compatible with this reaction. The product of 4-imino-β-lactam derivatives can be readily converted to 2-aminoquinoline which exists extensively in pharmaceutical drugs and natural products.

Microwave-assisted synthesis of the (E)-α-methylalkenoate framework from multifunctionalized allylic phosphonium salts

A convenient and general microwave-assisted method for the synthesis of stereochemically defined α-methylalkenoic acids and esters from allylic phosphonium salts in a basic aqueous medium is described. A selective preparation of acids or esters was dependent on the base (NaOH or NaHCO 3) employed in the reaction and could be achieved with good to excellent yields under mild conditions in the absence of hydrides and reducing agents.