25871-52-7

Basic information

• Product Name: Benzofuran, 5-methyl-2-phenyl-
• Synonyms: 5-methyl-2-phenylbenzofuran;5-methyl-2-phenyl-1-benzofuran
• CAS NO: 25871-52-7
• Molecular Formula: C₁₅H₁₂O
• Molecular Weight: 208.26
• Mol File: 25871-52-7.mol
• Article Data: 42

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzofuran, 5-methyl-2-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzofuran, 5-methyl-2-phenyl-(25871-52-7)
• EPA Substance Registry System: Benzofuran, 5-methyl-2-phenyl-(25871-52-7)

Safety Data

• Hazardous Substances Data: 25871-52-7(Hazardous Substances Data)

Upstream product

• 613-84-3 2-hydroxy-5-methylbenzaldehyde 
• 4755-72-0 Chloro-phenyl-acetic acid 
• 14538-45-5 2-(4-methylphenoxy)acetophenone 
• 122778-92-1 2-(2-Hydroxy-5-methylphenyl)-1-phenylethin 
• 63136-70-9 5-methyl-2-phenyl-3(2H)-benzofuranone 
• 122778-73-8 3-(2-Hydroxy-5-methylphenyl)-2-phenylcyclopropenon 
• 16188-57-1 2-iodo-4-methylphenol 
• 536-74-3 phenylacetylene 
• 106-44-5 p-cresol 
• 24258-63-7 1-(2-hydroxy-5-methylphenyl)-2-phenylethanone 
• 66502-11-2 2-isopropylsulfanyl-1-phenyl-ethanone 
• 121045-46-3 2-(isopropylthio)-1-phenylethan-1-ol 
• 121045-17-8 1-acetoxy-1-phenyl-2-isopropylthioethane 
• 532-27-4 1-chloroacetophenone 

Downstream Products

• 152862-81-2 5-Bromomethyl-2-phenyl-benzofuran 
• 50543-46-9 2-phenyl-3-acetyl-5-methylbenzofuran 
• 749789-37-5 2-phenyl-3-[3-(dimethylamino)propionyl]-5-methylbenzofuran 
• 1191950-83-0 5-methyl-2-phenyl-3-(phenylthio)benzofuran 

Relevant articles and documents

Acid-promoted selective synthesis of trifluoromethylselenolated benzofurans with Se-(trifluoromethyl) 4-methylbenzenesulfonoselenoate

A Br?nsted acid-promoted trifluoromethylselenolation of benzofurans was disclosed by using Se-(trifluoromethyl) 4-methylbenzenesulfonoselenoate as a stable and easily prepared electrophilic trifluoromethylselenolating reagent. A wide range of SeCF3-substituted benzofuran derivatives were obtained in moderate to good yields with excellent regioselectivity. The tandem cyclization/trifluoromethylselenolation procedure of 1-methoxy-2-(arylethynyl)benzenes were also realized by engaging FeCl3 as the catalyst.

Synthesis and biological evaluation of 2-arylbenzofuran derivatives as potential anti-Alzheimer’s disease agents

Alzheimer's disease (AD) is a type of progressive dementia caused by degeneration of the nervous system. A single target drug usually does not work well. Therefore, multi-target drugs are designed and developed so that one drug can specifically bind to mu

Preparation method of multi-substituted benzofuran derivative

The invention provides a preparation method of a multi-substituted benzofuran derivative. The multi-substituted benzofuran derivative is obtained by taking end alkyne and a halogenated phenol derivative as starting raw materials, copper salt as a catalyst and amino acid as an additive and performing coupling reaction in an organic solvent under the condition of adding alkali, wherein the catalystis CuX, X is iodine or bromine, the molar ratio of the catalyst to the halogenated phenol derivative is (0.001-0.5):1, the molar ratio of the amino acid to the catalyst is (0.1-3):1, the molar ratio of the halogenated phenol derivative to the end alkyne is (1-1.5):1, and the reaction temperature is 30 to 150 DEG C. An expensive palladium catalyst liable to cause environmental pollution is not used. The method is simple in process and high in operability, and has a good industrial application prospect.