258824-32-7

Basic information

• Product Name: 3-[4-(3-chloro-phenyl)-piperazin-1-yl]-1-(5-phenyl-1-pyrimidin-2-yl-1H-pyrazol-4-yl)-propan-1-one
• CAS NO: 258824-32-7
• Molecular Weight: 472.977
• Mol File: 258824-32-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-[4-(3-chloro-phenyl)-piperazin-1-yl]-1-(5-phenyl-1-pyrimidin-2-yl-1H-pyrazol-4-yl)-propan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[4-(3-chloro-phenyl)-piperazin-1-yl]-1-(5-phenyl-1-pyrimidin-2-yl-1H-pyrazol-4-yl)-propan-1-one(258824-32-7)
• EPA Substance Registry System: 3-[4-(3-chloro-phenyl)-piperazin-1-yl]-1-(5-phenyl-1-pyrimidin-2-yl-1H-pyrazol-4-yl)-propan-1-one(258824-32-7)

Safety Data

• Hazardous Substances Data: 258824-32-7(Hazardous Substances Data)

Upstream product

• 93-91-4 1-phenylbutan-1,3-dione 
• 7504-94-1 2-pyrimidinylhydrazine 
• 50-00-0 formaldehyd 
• 59068-33-6 2-ethoxymethylene-1-phenyl-1,3-butanedione 
• 13078-15-4 1-(3-chlorophenyl)piperazine hydrochloride 

Relevant articles and documents

Synthesis and antitumor activity of novel pyrimidinyl pyrazole derivatives

Novel pyrimidinyl pyrazole derivatives were synthesized and examined for cytotoxic and antitumor activity. Mannich reaction was employed to construct this scaffold. Among the compounds synthesized, a series of propene derivatives exhibited a potent cytotoxic activity against some tumor cell lines including multidrug resistant cell lines due to the overexpression of P-glycoprotein. The vinyl bond moiety in the scaffold was believed to be required for the cytotoxic activity. Among them, compound 14g, when administered intraperitoneaily, showed potent antitumor activity against the malignant ascites caused by intraperitoneal inoculation of P388 cells in mice. This compound also showed high activity against a solid tumor Meth A mouse fibrosarcoma when administered both intraperitoneaily and orally.