258842-80-7

Basic information

• Product Name: 5-{(2,6-dichloro-3-chloroacetylamino)benzyloxy}isoquinoline
• Synonyms: 5-{(2,6-dichloro-3-chloroacetylamino)benzyloxy}isoquinoline
• CAS NO: 258842-80-7
• Molecular Weight: 395.672
• Mol File: 258842-80-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-{(2,6-dichloro-3-chloroacetylamino)benzyloxy}isoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 5-{(2,6-dichloro-3-chloroacetylamino)benzyloxy}isoquinoline(258842-80-7)
• EPA Substance Registry System: 5-{(2,6-dichloro-3-chloroacetylamino)benzyloxy}isoquinoline(258842-80-7)

Safety Data

• Hazardous Substances Data: 258842-80-7(Hazardous Substances Data)

Upstream product

• 2439-04-5 5-hydroxyisoquinoline 
• 149976-78-3 2,6-dichloro-1-methanesulfonyloxymethyl-3-nitrobenzene 
• 541-88-8 Chloroacetic anhydride 
• 206883-01-4 5-(3-amino-2,6-dichlorobenzyloxy)isoquinoline 

Relevant articles and documents

Studies on anti-Helicobacter pylori agents. Part 1: Benzyloxyisoquinoline derivatives

The synthesis and optimization of the anti-Helicobacter pylori activity of a novel series of benzyloxyisoquinoline derivatives that was discovered by a random screening process, are described. In the in vitro assay, compound 10c containing a 3-acetamido-2,6-dichlorobenzyl substituent was found to have extremely potent activity against H. pylori and no activity against other common bacteria. The anti-H. pylori activity of 10c was superior to that of amoxicillin (AMPC) (1) and clarithromycin (CAM) (2). However, 10c did not show in vivo efficacy in a mouse infection model; a feature attributed to the lack of strong bactericidal activity at short contact times. (C) 1999 Elsevier Science Ltd.