258843-61-7

Basic information

• Product Name: Butanoic acid, 4-[3-[5-(4-methyl-1-piperazinyl)[2,5'-bi-1H-benzimidazol]-2'-yl]phenoxy]-, phenylmethyl ester
• CAS NO: 258843-61-7
• Molecular Formula: C36H36N6O3
• Molecular Weight: 600.72
• Mol File: 258843-61-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Butanoic acid, 4-[3-[5-(4-methyl-1-piperazinyl)[2,5'-bi-1H-benzimidazol]-2'-yl]phenoxy]-, phenylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Butanoic acid, 4-[3-[5-(4-methyl-1-piperazinyl)[2,5'-bi-1H-benzimidazol]-2'-yl]phenoxy]-, phenylmethyl ester(258843-61-7)
• EPA Substance Registry System: Butanoic acid, 4-[3-[5-(4-methyl-1-piperazinyl)[2,5'-bi-1H-benzimidazol]-2'-yl]phenoxy]-, phenylmethyl ester(258843-61-7)

Safety Data

• Hazardous Substances Data: 258843-61-7(Hazardous Substances Data)

Upstream product

• 100-83-4 meta-hydroxybenzaldehyde 
• 91970-62-6 benzyl 4-hydroxybutanoate 
• 23491-49-8 4-<5'-(4''-methylpiperazin-1''-yl)benzimidazol-2'-yl>benzene-1,2-diamine 
• 258843-60-6 3-(3-(benzyloxycarbonyl)propyloxy)benzaldehyde 

Downstream Products

• 258843-62-8 4-(3-(6-(4-methylpiperazin-1-yl)-1H,3′H-[2,5′-bibenzo[d]imidazol]-2′-yl)phenoxy)butanoic acid 

Relevant articles and documents

Synthesis of fluorescent microgonotropens (FMGTs) and their interactions with dsDNA

A new class of microgonotropen compounds (FMGTs), which fluoresce upon binding to dsDNA, is introduced. The FMGTs consist of a minor groove binding moiety based upon Hoescht 33258 covalently attached to a polyamine chain capable of interacting with the phosphodiester backbone of dsDNA. The interactions of FMGTs with dsDNA were investigated by fluorescence and UV spectroscopy. Several different dsDNA oligomers were studied to determine the effect of binding site sequence on stoichiometry and binding affinity. The FMGTs were found to bind a dsDNA oligomer that contained the sequence 5'-AATTT-3' with FMGT:dsDNA stoichiometries equal to 2:1 or 3:1. Hoechst 33258 bound the same dsDNA oligomer with a 1:1 stoichiometry. The second and third order equilibrium constants for complexation were determined to be Log(K1K2)=17.9M-2 and Log(K1K2K3)=26.1M-3, respectively, for two of strongest binding FMGTs. From thermal melting experiments ΔT(m) for Hoechst 33258 was determined to be 10°C while the ΔT(m) values for FMGTs ranged from 20-26°C indicating the greater stability of the latter. Copyright (C) 2000 Elsevier Science Ltd.