258848-35-0Relevant articles and documents
Imidazole-containing diarylether and diarylsulfone inhibitors of farnesyl-protein transferase
Dinsmore, Christopher J.,Williams, Theresa M.,O'Neill, Timothy J.,Liu, Dongming,Rands, Elaine,Culberson, J. Christopher,Lobell, Robert B.,Koblan, Kenneth S.,Kohl, Nancy E.,Gibbs, Jackson B.,Oliff, Allen I.,Graham, Samuel L.,Hartman, George D.
, p. 3301 - 3306 (2007/10/03)
The design and syntheses of non-thiol inhibitors of farnesyl-protein transferase are described. Optimization of cysteine-substituted diarylethers led to highly potent imidazole-containing diarylethers and diarylsulfones. Polar diaryl linkers dramatically