258870-43-8

Basic information

• Product Name: Carbamic acid, [(3S)-hexahydro-2-oxo-1-phenyl-1H-azepin-3-yl]-, 1,1-dimethylethyl ester
• CAS NO: 258870-43-8
• Molecular Formula: C17H24N2O3
• Molecular Weight: 304.389
• Mol File: 258870-43-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [(3S)-hexahydro-2-oxo-1-phenyl-1H-azepin-3-yl]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [(3S)-hexahydro-2-oxo-1-phenyl-1H-azepin-3-yl]-, 1,1-dimethylethyl ester(258870-43-8)
• EPA Substance Registry System: Carbamic acid, [(3S)-hexahydro-2-oxo-1-phenyl-1H-azepin-3-yl]-, 1,1-dimethylethyl ester(258870-43-8)

Safety Data

• Hazardous Substances Data: 258870-43-8(Hazardous Substances Data)

Upstream product

• 21568-87-6 2-aminocaprolactam 
• 24424-99-5 di-tert-butyl dicarbonate 
• 603-33-8 triphenylbismuthane 
• 76944-95-1 tert-butyl N-[(3S)-2-oxoazepan-3-yl]carbamate 

Downstream Products

• 258870-44-9 (S)-1-phenyl-2-oxo-3-amino-azepine 

Relevant articles and documents

Parallel liquid synthesis of N,N′-disubstituted 3-amino azepin-2-ones as potent and specific farnesyl transferase inhibitors

A rapid structure-activity study was performed by parallel liquid synthesis on N,N′-disubstitution of 3-amino azepin-2-one to afford potent and specific farnesyl transferase inhibitors with low nM enzymatic and cellular activities. The activities of the selected compounds were validated in vivo, and compounds 41a and 44a presented significant antitumour activity.