258878-27-2

Basic information

• Product Name: 4-(2-benzyloxy)-5-(4-biphenyl)-3-methyl-1,2,4-triazole
• Synonyms: 4-(2-benzyloxy)-5-(4-biphenyl)-3-methyl-1,2,4-triazole
• CAS NO: 258878-27-2
• Molecular Weight: 417.51
• Mol File: 258878-27-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-(2-benzyloxy)-5-(4-biphenyl)-3-methyl-1,2,4-triazole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-benzyloxy)-5-(4-biphenyl)-3-methyl-1,2,4-triazole(258878-27-2)
• EPA Substance Registry System: 4-(2-benzyloxy)-5-(4-biphenyl)-3-methyl-1,2,4-triazole(258878-27-2)

Safety Data

• Hazardous Substances Data: 258878-27-2(Hazardous Substances Data)

Upstream product

• 92-92-2 biphenyl-4-carboxylic acid 
• 14002-51-8 4-biphenyl-carboxylic acid chloride 
• 20012-63-9 o-(benzyloxy)aniline 
• 258879-14-0 2-(benzyloxy)thioacetanilide 
• 614-80-2 2-(acetylamino)phenol 
• 34288-19-2 N-(2-(benzyloxy)phenyl)acetamide 
• 18622-23-6 4-phenylbenzohydrazide 

Downstream Products

• 258879-00-4 5-(4-biphenyl)-3-methyl-4-{2-[3-(4-pyridyl)propoxy]phenyl}-1,2,4-triazole 
• 354153-14-3 5-(4-biphenyl)-4-[2-(6-bromohexyloxy)phenyl]-3-methyl-1,2,4-triazole 
• 258878-50-1 1-{6-[2-(3-biphenyl-4-yl-5-methyl-[1,2,4]triazol-4-yl)-phenoxy]-hexyl}-4-methyl-piperazine 
• 784213-18-9 5-(4-biphenyl)-3-methyl-4-{2-[2-(1-trityl-4-piperidyl)ethoxy]phenyl}-1,2,4-triazole 

Relevant articles and documents

Discovery of 4,5-diphenyl-1,2,4-triazole derivatives as a novel class of selective antagonists for the human V(1A) receptor.

In the search for a novel class of selective antagonists for the human V(1A) receptor, high-throughput screening (HTS) of the Yamanouchi chemical library using CHO cells expressing the cloned human V(1A) (hV(1A)) receptor led to the discovery of 5-(4-biphenyl)-4-(2-methoxyphenyl)-3-methyl-1,2,4-triazole (3) which possessed the novel 4,5-diphenyl-1,2,4-triazole structure. Subsequent structure-activity relationships studies on a series of the 4,5-diphenyl-1,2,4-triazole derivatives related to 3 revealed that the 4,5-diphenyl-1,2,4-triazole structure played an essential role in exerting high affinity for the hV(1A) receptor and that introduction of a basic amine moiety to the methoxy part of the 4-phenyl ring was effective in the improvement of both affinity for the hV(1A) receptor and selectivity versus the hV(2) receptor. Compound 3 and the 2-(morphorino)ethoxy derivative (11b) were shown to be antagonists for the hV(1A) receptor, from their effects on AVP-induced [Ca(2+)](i) response in CHO cells expressing the hV(1A) receptor.