25911-74-4

Basic information

• Product Name: 2-AMINO-3-AMINOMETHYLPYRAZINE
• Synonyms: 2-AMINO-3-AMINOMETHYLPYRAZINE;3-(AMINOMETHYL)PYRAZIN-2-AMINE;3-Amino-2-pyrazinemethanamine
• CAS NO: 25911-74-4
• Molecular Formula: C₅H₈N₄
• Molecular Weight: 124.14
• Mol File: 25911-74-4.mol
• Article Data: 1

Chemical Properties

• Melting Point: 84-85 °C
• Boiling Point: 314.8±37.0 °C(Predicted)
• Appearance: /
• Density: 1.264±0.06 g/cm3(Predicted)
• PKA: 6.70±0.29(Predicted)
• CAS DataBase Reference: 2-AMINO-3-AMINOMETHYLPYRAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-3-AMINOMETHYLPYRAZINE(25911-74-4)
• EPA Substance Registry System: 2-AMINO-3-AMINOMETHYLPYRAZINE(25911-74-4)

Safety Data

• Hazardous Substances Data: 25911-74-4(Hazardous Substances Data)

Usage

General Description

2-Amino-3-aminomethylpyrazine is a chemical compound with the molecular formula C5H8N4. It is a heterocyclic aromatic amine that is commonly used as a flavor and fragrance ingredient. It is a white to light brown crystalline powder with a characteristic odor. 2-Amino-3-aminomethylpyrazine is used in the food industry to impart a roasted, nutty, and meaty flavor to a variety of products, including coffee, chocolate, and grilled meats. It is also utilized in the production of pharmaceuticals and as a building block in organic synthesis. However, the compound can be hazardous if not handled properly and should be used with caution in industrial and laboratory settings.

Upstream product

• 25911-65-3 2-amino-3-pyrazinonitrile 

Downstream Products

• 90176-11-7 N-(3-aminopyrazin-2-ylmethyl)-2,5-anhydro-3,4,6-tri-O-benzoyl-D-allonamide 
• 135291-47-3 2-Benzyloxymethyl-3,4-dihydro-pteridine 
• 135291-72-4 (3,4-Dihydro-pteridin-2-ylmethyl)-phenyl-amine 
• 135291-13-3 2-Phenoxymethyl-3,4-dihydro-pteridine 
• 135291-37-1 2-p-Tolyloxymethyl-3,4-dihydro-pteridine 
• 135291-35-9 2-m-Tolyloxymethyl-3,4-dihydro-pteridine 
• 135291-43-9 2-(4-Methoxy-phenoxymethyl)-3,4-dihydro-pteridine 
• 135291-29-1 2-(3,5-Dichloro-phenoxymethyl)-3,4-dihydro-pteridine 
• 135291-78-0 (3,4-Dihydro-pteridin-2-yl)-phenyl-methanol 
• 135290-79-8 2-Cyclohexyloxymethyl-3,4-dihydro-pteridine 
• 135291-64-4 2-Phenylsulfanylmethyl-3,4-dihydro-pteridine 
• 144288-36-8 2-Benzylsulfanylmethyl-3,4-dihydro-pteridine 
• 135291-56-4 2-(4-Methyl-benzyloxymethyl)-3,4-dihydro-pteridine 
• 135291-69-9 2-Benzenesulfonylmethyl-3,4-dihydro-pteridine 

Relevant articles and documents

Novel 1-(2-aminopyrazin-3-yl)methyl-2-thioureas as potent inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2)

Novel 1-(2-aminopyrazin-3-yl)methyl-2-thioureas are described as inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2). These compounds demonstrate potent in vitro activity against the enzyme with IC50 values as low as 15 nM, and suppress expression of TNFα in THP-1 cells and in vivo in an acute inflammation model in mice. The synthesis, structure-activity relationship (SAR), and biological evaluation of these compounds are discussed.