259181-78-7Relevant articles and documents
Stereoselective syntheses of 13E and 13Z retinoic acids via a new intermediate C-15 β-methylenealdehyde
Valla, Alain,Andriamialisoa, Zo,Prat, Virginie,Laurent, Alain,Giraud, Michel,Labia, Roger,Potier, Pierre
, p. 7211 - 7215 (2000)
The methylene-de-oxo-bisubstitution reaction between dimethyl isopropylidene malonate and the C-15 β-methylenealdehyde 1 which could serve as substitute for E β-ionylideneacetaldehyde 2, produces stereoselectively the E,E olefin. Hence, new stereoselective syntheses of 13 E and 13 Z retinoic acids were described. (C) 2000 Elsevier Science Ltd.