25967-29-7

Basic information

• Product Name: 2H-1,4-BENZODIAZEPIN-2-ONE, 7-CHLORO-1-(CYCLOPROPYLMETHYL)-5-(2-FLUOROPHENYL)-1,3-DIHYDRO-
• Synonyms: 2H-1,4-BENZODIAZEPIN-2-ONE, 7-CHLORO-1-(CYCLOPROPYLMETHYL)-5-(2-FLUOROPHENYL)-1,3-DIHYDRO-;Flutoprazepam;7-Chloro-1-(cyclopropylmethyl)-5-(2-fluorophenyl)-1，3-dihydro-2H-1，4-benzodiazepin-2-one;ID-1937;KB-509;Restar;Restas;KB-509P
• CAS NO: 25967-29-7
• Molecular Formula: C₁₉H₁₆ClFN₂O
• Molecular Weight: 342.79
• Mol File: 25967-29-7.mol
• Article Data: 1

Chemical Properties

• Melting Point: 118-122°
• Boiling Point: 539.3 °C at 760 mmHg
• Flash Point: 279.9 °C
• Appearance: /
• Density: 1.2683 (estimate)
• Vapor Pressure: 1.07E-11mmHg at 25°C
• Refractive Index: 1.661
• PKA: 1.93±0.35(Predicted)
• CAS DataBase Reference: 2H-1,4-BENZODIAZEPIN-2-ONE, 7-CHLORO-1-(CYCLOPROPYLMETHYL)-5-(2-FLUOROPHENYL)-1,3-DIHYDRO-(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-1,4-BENZODIAZEPIN-2-ONE, 7-CHLORO-1-(CYCLOPROPYLMETHYL)-5-(2-FLUOROPHENYL)-1,3-DIHYDRO-(25967-29-7)
• EPA Substance Registry System: 2H-1,4-BENZODIAZEPIN-2-ONE, 7-CHLORO-1-(CYCLOPROPYLMETHYL)-5-(2-FLUOROPHENYL)-1,3-DIHYDRO-(25967-29-7)

Safety Data

• Hazardous Substances Data: 25967-29-7(Hazardous Substances Data)

Usage

Description

2H-1,4-BENZODIAZEPIN-2-ONE, 7-CHLORO-1-(CYCLOPROPYLMETHYL)-5-(2-FLUOROPHENYL)-1,3-DIHYDRO-, also known as Flutoprazepam, is a benzodiazepine anti-anxiety agent with a longer duration of action and higher potency compared to diazepam. It is characterized by its unique chemical structure, which includes a 7-chloro substitution, a cyclopropymethyl group at the 1-position, and a 2-fluorophenyl group at the 5-position. 2H-1,4-BENZODIAZEPIN-2-ONE, 7-CHLORO-1-(CYCLOPROPYLMETHYL)-5-(2-FLUOROPHENYL)-1,3-DIHYDROis used in the pharmaceutical industry for its anxiolytic and sedative properties.

Uses

Used in Pharmaceutical Industry:
Flutoprazepam is used as an anxiolytic agent for the treatment of anxiety disorders. Its application is based on its ability to modulate the GABA receptor, leading to a calming effect on the central nervous system and reducing anxiety symptoms.
Used in Sleep Aid Applications:
In addition to its anxiolytic properties, Flutoprazepam is also used as a sedative to help individuals with insomnia or other sleep disorders. Its longer duration of action and higher potency compared to diazepam make it an effective option for promoting sleep and improving sleep quality.
Brand Name:
Flutoprazepam is marketed under the brand name RESTAS, which is a widely recognized and prescribed medication for anxiety and sleep-related issues.

Originator

Sumitomo (Japan)

InChI:InChI=1/C19H16ClFN2O/c20-13-7-8-17-15(9-13)19(14-3-1-2-4-16(14)21)22-10-18(24)23(17)11-12-5-6-12/h1-4,7-9,12H,5-6,10-11H2

Relevant articles and documents

Process for the preparation of 1,4-benzodiazepine derivatives

A 1,4-benzodiazepine derivative, or a pharmaceutically acceptable acid salt thereof, of the formula, SPC1 Wherein R1 is hydrogen, halogen, nitro or trifluoromethyl; R2 and R3 are independently hydrogen, halogen, lower alkyl or trifluoromethyl; R4 is lower alkyl, alkenyl, trihaloalkyl, alkoxyalkyl, alkenyloxyalkyl, alkoxyalkoxyalkyl, alkanoyloxyalkyl, cycloalkylalkyl, alkylthioalkyl, alkylsulfinylalkyl, alkylsulfonylalkyl or a group of the formula EQU1 in which R6 and R7 are independently lower alkyl, and n is an integer of 1 to 4; and R5 is hydrogen or lower alkyl, is obtained by reacting a benzophenone derivative of the formula, SPC2 Wherein R1, R2, R3 and R4 are as defined above, with a 2-isocyanatoacetyl chloride derivative of the formula EQU2 wherein R5 is as defined above.